Wegener’s granulomatosis (WG) is a rare disease that causes the walls of blood vessels to become inflamed, a condition called vasculitis. This limits blood flow to tissues and can affect any organ. The outlook is good with proper treatment, but without it, WG is fatal.
WG is a type of autoimmune disease. This means the body’s immune system attacks its own tissues. The cause is unknown.
WG does not appear to be passed from one generation to the next. It is more common in Caucasians, and in people of middle age.
Symptoms and their severity vary from one person to another. In most cases, ear, nose, and throat symptoms appear first. These symptoms do not respond to normal treatment and worsen over time.
WG can cause common cold- or flu-like symptoms such as:
Common respiratory tract symptoms associated with WG may include:
Your doctor will ask about your symptoms and medical history. A physical exam will be done. The doctor may do tests to rule out other conditions, determine which organs are involved, or to confirm the diagnosis. Tests may include:
Imaging tests to see internal body structures include
WG is treated with medications. Some are used to induce remission, while others are used for maintenance once remission is achieved.
Your doctor may recommend one or more of the following:
There are no current guidelines to prevent Wegener's granulomatosis.
National Institute of Allergy and Infectious Diseases (NIH)
Wegener’s Granulomatosis Association
Public Health Agency of Canada
The Arthritis Society
Granulomatosis with polyangiitis. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed.ebscohost.com/about/about-us. Updated August 6, 2013. Accessed August 7, 2013.
Granulomatosis with polyangiitis. National Institute of Allergy and Infectious Diseases website. Available at:
http://www.niaid.nih.gov/topics/gpa/pages/default.aspx. Updated July 31, 2013. Accessed August 7, 2013.
Granulomatosis with polyangiitis (GPA/Wegener's). Vasculitis Foundation website. Available at:
http://www.vasculitisfoundation.org/education/forms/granulomatosis-with-polyangiitis-gpa-wegeners. Updated September 2012. Accessed August 7, 2013.
Wegener’s granulomatosis? The Cleveland Clinic website. Available at:
http://www.clevelandclinic.org/health/health-info/docs/0200/0214.asp?index=4757. Accessed August 7, 2013.
Last reviewed August 2013 by Michael J. Fucci, DO; Brian Randall, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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