Karen Schroeder Kassel, MS, RD, MEd
Folate, also known as folic acid, is a B vitamin that is essential for good health.
Folic acid plays an extremely important role in preventing birth defects. Low blood levels of folate during pregnancy can cause neural tube defects—anencephaly and
spina bifida. Because these defects occur in the first month of pregnancy, before a woman knows she is pregnant, it is important for any woman of childbearing age to get 400 mcg (micrograms) of folic acid daily. Pairing folate with iron may reduce the number of infants born with low birth weight and reduce infant mortality.
Folate deficiency can also result in megaloblastic anemia. This is due to the role that folic acid plays in the DNA synthesis and red blood cell division. Without folic acid new red blood cells can’t divide and thus stay large and immature.
Foods with the high amounts of folate include:
To help increase your intake of folate:
ChooseMyPlate.gov—US Department of Agriculture
EatRight.org—Academy of Nutrition and Dietetics
Dietitians of Canada
Folate. Office of Dietary Supplements website. Available at: http://ods.od.nih.gov/factsheets/Folate-HealthProfessional. Accessed August 28, 2012.
Folate deficiency. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated December 15, 2012. Accessed August 28, 2012.
Folic acid. Centers for Disease Control and Prevention website. Available at:
http://www.cdc.gov/ncbddd/folicacid/index.html. Updated July 14, 2014. Accessed July 23, 2014.
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Herrmann W. Significance of hyperhomocysteinemia.
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Micronutrient needs during pregnancy and lactation. Oregon State University Linus Pauling Institute website. Available at: http://lpi.oregonstate.edu/infocenter/lifestages/pregnancyandlactation/index.html. Updated July 2011. Accessed July 23, 2014.
Roth C, Magnus P, Schjolberg S, et al. Folic acid supplements in pregnancy and severe language delay in children. JAMA. 2011 Oct 12;306(14):1566-73.
Toole J, Malinow R, Chambless L, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial.
11/6/2009 DynaMed's Systematic Literature Surveillance
http://www.ebscohost.com/dynamed: Christian P, Stewart CP, LeClerq SC, et al. Antenatal and postnatal iron supplementation and childhood mortality in rural Nepal: a prospective follow-up in a randomized, controlled community trial. Am J Epidemiol. 2009;170:1127-1136.
Christian P, Khatry SK, Katz J, et al. Effects of alternative maternal micronutrient supplements on low birth weight in rural Nepal: double blind randomised community trial. BMJ. 2003;326(7389):571.
10/21/2011 DynaMed's Systematic Literature Surveillance
http://www.ebscohost.com/dynamed: Roth C, Magnus P, Schjølberg S, et al. Folic acid supplements in pregnancy and severe language delay in children. JAMA. 2011;306(14):1566-1573.
Last reviewed July 2014 by Michael Woods, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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