Though rare, certain types of non-Hodgkin lymphoma may be treated with surgery. This may be the case when the cancer is localized to an organ and has not spread, or if other treatment methods fail. Examples include:

  • Removing tumors from the stomach in those with gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
  • Splenectomy in those with splenic marginal zone lymphoma. It is possible to live without a spleen, but it increases the risk of certain bacterial infections, such as pneumonia. Extra protection against some infections can be attained with vaccines and lifestyle changes.

Surgery is usually done in combination with other treatments.