Jondavid Pollock, MD, PhD
is the treatment modality that employs drugs to kill cancer cells. The drugs enter the bloodstream and travel through the body in order to kill cancer cells. The side effects of chemotherapy come from the fact that the drugs destroy normal cells, as well.
Chemotherapy for testicular cancer usually involves some combination of bleomycin, etoposide,
cisplatin, ifosfamide, and
carboplatin. For some tumors, very high-dose chemotherapy (sufficient to eradicate bone marrow cells) is given, followed by stem cell transplant.
Chemotherapy is usually given by IV, but some forms can be given by mouth. Your oncologist will tell you how many cycles or courses of chemotherapy are best for you. Usually there are between 3-4 cycles of chemotherapy given when the chemotherapy is the only form of treatment.
The side effects and amount of time required in the doctor’s office depend on the type of chemotherapy you receive, as well as how many cycles you receive and how often. The most common chemotherapy-associated side effects are:
Most of these side effects are temporary, though some may be permanent. Discuss the implications of chemotherapy side effects with your oncologist.
Chemotherapy is given primarily after surgery in the treatment of nonseminomas. Sometimes it is also given if the tumor is very large or it has spread to the lung, brain, or other organs.
Chemotherapy for testicular cancer. American Cancer Society website. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/003142-pdf.pdf. Accessed September 8, 2016.
Drugs approved for testicular cancer. National Cancer Institute website. Available at: http://www.cancer.gov/about-cancer/treatment/drugs/testicular. Updated August 18, 2016. Accessed September 8, 2016.
Testicular cancer. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T907377/Testicular-cancer. Updated January 12, 2016. Accessed October 5, 2016.
8/11/2011 DynaMed Plus Systematic Literature Surveillance
http://www.dynamed.com/topics/dmp~AN~T907377/Testicular-cancer: Oliver RT, Mead GM, Rustin GJ, et al. Randomized trial of carboplatin versus radiotherapy for stage I seminoma: mature results on relapse and contralateral testis cancer rates in MRC TE19/EORTC 30982 study (ISRCTN27163214. J Clin Oncol. 2011;29(8):957-962.
Last reviewed September 2016 by Mohei Abouzied, MD
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