Canker sores are small ulcers in the mouth caused by an assortment of viruses. A susceptibility to canker sores tends to run in families. No successful conventional treatment is available.
A highly preliminary study suggests that a chemically altered form of the herb licorice known as
deglycyrrhizinated licorice (DGL) may be useful for speeding the resolution of canker sores.1 And, in a second, better designed trial employing a dissolving adhesive patch with glycyrrhiza root extract, researchers noted an improvement in ulcer size and pain compared to the use of a placebo patch.8
A product containing vitamins and minerals as well as the herbs paprika,
pumpkin seed has been used in Scandinavia for many years as a treatment for various mouth-related conditions. A small 6-month study reported that use of this product could reduce frequency of canker sores.2 However, two subsequent studies failed to find any meaningful benefit.3-4
One small double-blind study found benefits with an extract of the bark of the red mangrove tree,
A study performed in Iraq reported benefits through use of a mouthwash containing 5% lactic acid.7
Other herbs and supplements sometimes recommended for canker sores but lacking supporting evidence include
slippery elm, and
One study failed to find that alpha-linolenic acid from perilla oil reduced incidence of canker sores.6
In a small randomized trial with 50 people wiht recurrent canker sores, omega-3 fatty acids (1 gram, 3 times per day for 6 months) was associated with improvement in the number of ulcers, pain level of ulcers, and healing time of ulcers by up to 3 months when compared to placebo.9
Das SK, Das V, Gulati AK, et al. Deglycyrrhizinated liquorice in aphthous ulcers.
J Assoc Physicians India. 1989;37:647.
Pedersen A, Hougen HP, Klausen B et al. LongoVital in the prevention of recurrent aphthous ulceration.
J Oral Pathol Med. 1990;19:371-375.
Brateli J, Hakeberg M, Jontell M et al. The effect of LongoVital on recurrent aphthous stomatitis in a controlled clinical trial.
Oral Health Prev Dent. 2005;3:3-8.
Kolseth I, Herlofson B, Pedersen A et al. Norwegian LongoVital and recurrent aphthous ulceration: a randomized, double-blind, placebo-controlled study.
de Armas E, Sarracent Y, Marrero E et al. Efficacy of Rhizophora mangle aqueous bark extract (RMABE) in the treatment of aphthous ulcers: a pilot study.
Curr Med Res Opin.
Hamazaki K, Itomura M, Hamazaki T et al. Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial.
2006 Feb 9. [Epub ahead of print]
Sharquie KE, Al-Tammimy SM, Al-Mashhadani S, et al. Lactic acid 5 percent mouthwash is an effective mode of therapy in treatment of recurrent aphthous ulcerations.
Dermatol Online J.
Martin MD, Sherman J, van der Ven P, et al. A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers.
2008;56:206-210;quiz 211-212, 224.
El Khouli AM1, El-Gendy EA. Efficacy of omega-3 in treatment of recurrent aphthous stomatitis and improvement of quality of life: a randomized, double-blind, placebo-controlled study.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117(2):191-196.
Last reviewed September 2014 by EBSCO CAM Review Board
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.