Native Americans used tea made from elderberry flowers to treat respiratory
infections. They also used the leaves and flowers in poultices applied to
wounds, and the bark, suitably aged, as a laxative. The berries are frequently
made into beverages, pies, and preserves, but they have also been used to treat
A product containing elderberry, as well as small amounts of
bee propolis, has been widely marketed as a
cold and flu remedy. Weak evidence suggests that this mixture may stimulate the immune system and also inhibit viral growth.1 In a preliminary double-blind study, this mixture was found to reduce symptoms and speed recovery from influenza A, the type of influenza for which flu shots are given.5 A few of the participants in this study had influenza B (a milder form of influenza), and the elderberry mixture appeared to be helpful for them as well. Another preliminary double-blind study evaluated people with influenza B, and also found benefit.2
Elderberry has also shown some preliminary promise for use in other viral infections, including
Based on promising results in an
study, researchers performed a small
double-blind, placebo-controlled study on the potential benefits of elderberry for improving cholesterol levels.6
Unfortunately, at the dose used, no benefits were evident.
Elderberry-flower tea is made by steeping 3 to 5 g of dried flowers in 1 cup of boiling water for 10 to 15 minutes. A typical dosage is 1 cup 3 times daily. Standardized extracts should be taken according to the directions on the product's label.
Elderberry flowers are generally regarded as safe. Side effects are rare and consist
primarily of occasional mild gastrointestinal distress or allergic reactions.
Nonetheless, safety in young children, pregnant or nursing women, or those
with severe liver or kidney disease has not been established.
Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines.
Eur Cytokine Netw.
Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (
L.) during an outbreak of influenza B Panama.
J Altern Complement Med. 1995;1:361–369.
Shapira-Nahor B. The effect of Sambucol on HIV infection in vitro. Annual Israel Congress of Microbiology, February 6–7, 1995.
Morag A, Mumcuoglu M, Baybikov T, et al. Inhibition of sensitive and acyclovir-resistant HSV-1 strains by an elderberry extract in vitro [abstract].
Zakay-Rones Z., Thom E., Wollan T., et al. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections.
Journal of International Medical Research. 2004;32:132-140.
Murkovic M, Abuja PM, Bergmann AR, et al. Effects of elderberry juice on fasting and postprandial serum lipids and low-density lipoprotein oxidation in healthy volunteers: a randomized, double-blind, placebo-controlled study.
Eur J Clin Nutr. 2004;58:244-9.
Last reviewed September 2014 by EBSCO CAM Review Board
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.