(shingles) is an acute, painful infection caused by the varicella-zoster virus, the organism that causes chicken pox. It develops many years after the original chicken pox infection, typically in the elderly or those with compromised immune systems. The first sign may be a tingling feeling, itchiness, or shooting pain on an area of skin. A rash may then appear, with raised dots or blisters forming. When the rash is at its peak, rash symptoms can range from mild itching to extreme pain. People with shingles on the upper half of the face should seek medical attention, as the virus may cause damage to the eyes.
Shingles usually resolves without complications within 3 to 5 weeks. However, in some people, especially seniors, the pain may persist for months or years. This condition is known as post-herpetic neuralgia (PHN). It is thought to be caused by a continuing irritation of the nerves after the infection is over.
Conventional medical treatment for shingles includes antiviral drugs (acyclovir, famicyclovir, valacyclovir). When used properly, these lead to faster resolution of symptoms including lesions and acute neuralgia, and may reduce the incidence and severity of PHN.
(amitriptyline) are also prescribed to lessen shingles symptoms, and the former might help prevent PHN.
Individuals who do develop PHN may be treated with steroids, antidepressants, and topical creams (
see Capsaicin, below). In severe cases, nerve blocks might be used.
For the initial attack of shingles, proteolytic enzymes may be helpful. Capsaicin cream is an FDA-approved treatment for PHN.
There is some evidence that proteolytic enzymes may be helpful for the initial attack of shingles.
Proteolytic enzymes are produced by the pancreas to aid in digestion of protein, and certain foods also contain these enzymes. Besides their use in digestion, these enzymes may have some effects in the body as a whole when taken orally. The most-studied proteolytic enzymes include papain (from papaya),
(from pineapple), and
trypsin and chymotrypsin
(extracted from the pancreas of various animals).
double-blind study of 190 people with shingles compared proteolytic enzymes to the standard antiviral drug acyclovir.1
Participants were treated for 14 days and their pain was assessed at intervals. Although both groups had similar pain relief, the enzyme-treated group experienced fewer side effects.
Similar results were seen in another double-blind study in which 90 people were given either an injection of acyclovir or enzymes, followed by a course of oral medication for 7 days.2
Proteolytic enzymes are thought to benefit cases of shingles by decreasing the body's inflammatory response and regulating immune response to the virus.
For more information, including dosage and safety issues, see the full
Capsaicin, the "hot" in hot peppers, has been found effective for treating the pain related to PHN
9-11, and has been approved by the FDA for that purpose. Capsaicin is thought to work by inhibiting chemicals in nerve cells that transmit pain (for further detail on how this works, see the cayenne
Topical capsaicin cream is available in 2 strengths, 0.025 and 0.075%. Both preparations are indicated for use in neuralgia. The cream should be applied sparingly to the affected area three to four times daily. Treatment should continue for several weeks as the benefit may take a while to develop. Capsaicin creams are approved over-the-counter drugs and should be used as directed. Over-the-counter creams containing concentrated capsaicin are recognized as safe, but caution should be used near the eyes and mucous membranes. Mild to moderate burning may occur at first, but it decreases over time.
A transdermal patch containing a relatively high concentration of capsaicin (8%) has been developed. Compared to a low-concentration version (0.04%), this high-concentration patch was associated with significant improvements in pain in a trial involving 402 adults suffering with postherpetic neuralgia for at least 6 months.12
In a review of six randomized trials of 2,073 adults with postherpetic neuralgia or HIV-associated neuropathy, a high-dose capsaicin (8%) patch significantly improved pain symptoms for up to 12 weeks compared to a low-dose (0.04%) capsaicin patch.13
Adenosine monophosphate (AMP), a natural by-product of cell metabolism, has been studied as a possible treatment for initial shingles symptoms as well as PHN prevention.
In a double-blind,
placebo-controlled study of 32 people with shingles, AMP was injected 3 times a week for 4 weeks.4
At the end of the 4-week treatment period, 88% of those treated with AMP were pain-free versus only 43% in the placebo group; all participants still in pain were then given AMP, and no recurrence of pain was reported in 3 to 18 months of follow-up. However, this was a highly preliminary study, and more evidence is needed before AMP can be considered a proven treatment for shingles.
Oral AMP has not been tried for this condition.
Note: Do not self-inject AMP products meant for oral consumption.
B12 have also been suggested as possible treatments for PHN, but the evidence that they work is extremely weak.5–7
A single-blind, placebo-controlled study of 62 people with post-herpetic neuralgia failed to find any benefit with
Billigmann P. Enzyme therapy—an alternative in treatment of herpes zoster. A controlled study of 192 patients [translated from German].
Fortschr Med. 1995;113:43–48.
Kleine MW, Stauder GM, Beese EW. The intestinal absorption of orally administered hydrolytic enzymes and their effects in the treatment of acute herpes zoster as compared with those of oral acyclovir therapy.
Sklar SH, Blue WT, Alexander EJ, et al. Herpes zoster—the treatment and prevention of neuralgia with adenosine monophosphate.
Ayres S Jr, Mihan R. Post-herpes zoster neuralgia: response to vitamin E therapy [letter].
Arch Dermatol. 1973;108:855–856.
Cochrane T. Post-herpes zoster neuralgia: response to vitamin E therapy [letter].
Heyblon R. Vitamin B12 in herpes zoster.
Lewith GT, Field J, Machin D. Acupuncture compared with placebo in post-herpetic pain.
Watson CP, Evans RJ, Watt VR. Post-herpetic neuralgia and topical capsaicin.
Watson CP, Tyler KL, Bickers DR, et al. A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia.
Clin Ther. 1993;15:510-526.
Alper BS, Lewis PR. Treatment of postherpetic neuralgia: a systematic review of the literature.
J Fam Pract. 2002;51:121-128.
Backonja M, Wallace MS, Blonsky ER, et al. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study.
Irving G, Backonja M, et al. NGX-4010, a capsaicin 8% dermal patch, administered alone or in combination with systemic neuropathic pain medications, reduces pain in patients with postherpetic neuralgia.
Clin J Pain. 2012;28(2):101-107.
Last reviewed December 2015 by EBSCO CAM Review Board
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Information Services. All rights reserved.