Rosalyn Carson-DeWitt, MD
A risk factor is something that increases your chances of getting a disease or condition.
It is possible to develop bladder cancer with or without the risk factors listed below. However, the more risk factors you have, the greater your likelihood of developing bladder cancer. If you have a number of risk factors, ask your doctor what you can do to reduce your risk.
Risk factors for bladder cancer include the following:
A large number of cases of bladder cancer are associated with smoking tobacco. The risk of developing bladder cancer increases depending on how many years you have smoked, how many cigarettes you smoked per day, and whether you inhale the smoke.
Exposure to certain chemicals greatly increases a person’s risk of bladder cancer. Workers who are most likely to be exposed to such cancer-causing agents include the following:
Treatment with the drug cyclophosphamide can also increase your risk of bladder cancer.
This drug is used in
and to treat certain autoimmune disorders, such as
Pioglitazone also increases the risk of bladder cancer. This medication is used to treat type 2 diabetes.
Conditions that allow your bladder to be chronically irritated over a long period of time can increase your chance of developing bladder cancer. Irritating conditions include the following:
You may have a slightly increased risk of developing bladder cancer if you’ve had:
There is a risk of bladder cancer in those with diabetes. Manage your diabetes to reduce your risk.
Bladder cancer. American Cancer Society website. Available at:
http://www.cancer.org/cancer/bladdercancer/. Accessed June 5, 2013.
Bladder cancer. Urology Care Foundation website. Available at:
http://www.urologyhealth.org/urology/index.cfm?article=100. Updated March 2013. Accessed June 5, 2013.
What you need to know about bladder cancer. National Cancer Institute website. Available at
http://www.cancer.gov/cancerinfo/wyntk/bladder. Updated August 30, 2010. Accessed June 5, 2013.
12/9/2013 DynaMed's Systematic Literature Surveillance
http://www.ebscohost.com/dynamed: Zhu Z, Wang X, et al. Risk of bladder cancer in patients with diabetes mellitus: an updated meta-analysis of 36 observational studies. BMC Cancer. 2013 Jun 26;13:310.
Last reviewed May 2014 by Mohei Abouzied, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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