Ricker Polsdorfer, MD
Symptoms may not be present in early stages of MDS, but will appear as the disease progresses. If you experience any of these symptoms, do not assume it is due to MDS. Many of these symptoms can be caused by other conditions, like an iron deficiency or infection. It is still important to discuss these symptoms with your doctor. Early detection and treatment improve outcomes for both MDS and other health conditions.
Symptoms are mainly related to the low numbers of a particular blood cell. Each blood cell has a specific function in the body, so if they are not in a range that is considered normal, symptoms will appear.
The most common complication is anemia. It is because of a drop in the number of normal red blood cells, which decrease the body's ability to bring oxygen to body tissue. Symptoms of anemia may include:
In people with
coronary artery disease, anemia may cause:
In people with a history of blood vessel problems in the brain, anemia may increase the risk of:
A drop in the number of normal white blood cells makes it harder for the body to fight infection. Symptoms may include:
A drop in the number of normal platelet cells makes it harder for blood to clot properly. Without clotting, even small injuries can lead to severe bleeding. Symptoms may include:
General information about myelodysplastic syndromes. National Cancer Institute website. Available at: http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Updated August 12, 2015. Accessed June 22, 2016.
Myelodysplastic syndrome. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114054/Myelodysplastic-syndrome-MDS. Updated May 16, 2016. Accessed June 21, 2016.
Myelodysplastic syndrome. Merck Manual Professional Version website Available at: http://www.merckmanuals.com/professional/hematology-and-oncology/leukemias/myelodysplastic-syndrome. Updated October 2014. Accessed June 22, 2016.
Myelodysplastic syndromes. American Cancer Society website. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/003122-pdf.pdf. Accessed June 22, 2016.
Understanding myelodysplastic syndromes (MDS). MDS Foundation website. Available at: http://www.mds-foundation.org/what-is-mds. Accessed June 22, 2016.
Last reviewed December 2015 by Mohei Abouzied, MD
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