Ricker Polsdorfer, MD
If esophageal cancer is localized and has not spread beyond the original site, surgical removal of the cancer is the most common treatment. The goal is to remove as much of the cancer as possible while preserving as much function of the esophagus as possible. It may also be done with chemoradiation, a combination of radiation therapy and chemotherapy to shrink the tumor before surgery or to try to kill off any remaining cancer cells after surgery. Surgical removal is not always an option since most esophageal cancers are found in advanced stages. In this case, surgery may be done as palliative care to improve the function of the esophagus.
High grade dysplasia is a change in cell structure that is a precursor to cancer. Surgery for high grade dysplasia and early stage cancer offer the best chance for a cure. Options include:
Small, noninvasive cancer can be removed during an endoscopy. A tube with a lighted tip and camera are inserted through the mouth and throat. It can also be inserted through small incisions in chest and/or abdomen if the surgeon needs to access the tumor from a different angle. The tumor is removed along with a margin of healthy tissue to try to ensure that all the cancer is completely removed. The doctor will examine and take samples of the removed tissue. Tissue samples will be examined under a microscope for the presence of cancer.
Photosensitizers, or light-sensitive molecules, are injected into the bloodstream. These molecules are absorbed by cells throughout the body, but tend to remain longest in cancer cells. When these molecules are exposed to a special red light, they cause cell damage and death. The light will be directed to the tumor using an endoscope.
An esophagectomy is the removal of part or all of the esophagus. The amount of tissue removed depends on the location and size of the tumor. In some cases, the stomach is stretched up into the chest and neck, and attached to the remaining part of the esophagus. If large amounts of tissue are removed, a plastic tube or intestinal tissue may be used to create a connection between the mouth and the stomach.
Nearby lymph nodes may also be removed and tested for the presence of cancer. Cancer in the lymph nodes means the cancer may have spread to other areas of the body.
Esophagectomies can be done as:
An esophagectomy is a long and difficult procedure that often has postoperative complications. It is important to seek out an experienced surgeon and hospital for this procedure.
can be inserted through the abdominal wall and directly into the stomach or small intestine. This is done when swallowing becomes difficult and nutritional needs are not able to be met. Nutritional support helps prevent starvation, as well as aspiration of material into the lungs.
The feeding tube can be placed as part of a scheduled surgery or done separately. The opening through the abdomen is called a stoma. The rubber tube from the stoma is fixed and secure. Complete, balanced liquid meals and medications can be delivered through the tube.
If a surgical cure is not an option, there are a few options available to help keep the esophageal channel open as long as possible. All of these procedures are done during an endoscopy.
ASGE Technology Committee, Kantsevoy SV, Adler DG, et al. Endoscopic mucosal resection and endoscopic submucosal dissection. Gastrointest Endosc. 2008;68(1):11-18.
Esophageal and esophagogastric junction cancer. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated August 10, 2015. Accessed December 17, 2015.
Esophageal cancer. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/gastrointestinal-disorders/tumors-of-the-gi-tract/esophageal-cancer. Updated July 2014. Accessed December 17, 2015.
Esophagus cancer. American Cancer Society website. Available at
http://www.cancer.org/acs/groups/cid/documents/webcontent/003098-pdf.pdf. Accessed December 17, 2015.
Kato H, Nakajima M.
Treatments for esophageal cancer: A review. Gen Thorac Cardiovasc Surg. 2013;61(6):330-335.
Lightdale CJ. Endoscopic treatments for early esophageal cancer. Gastroenterol Hepatol (NY). 2007;3(12):904-906.
Mackenzie DJ, Popplewell PK, Billingsley KG. Care of patients after esophagectomy. Crit Care Nurse. 2004;24(1):16-29.
Nakajima M, Kato H.
Treatment options for esophageal squamous cell carcinoma.
Expert Opin Pharmacother. 2013;14(10):1345-1354.
Treatment option overview. National Cancer Institute website. Available at: http://www.cancer.gov/types/esophageal/patient/esophageal-treatment-pdq#section/_159. Updated December 17, 2015. Accessed December 17, 2015.
Vignesh S, Hoffe SE, Meredith KL, et al. Endoscopic therapy of neoplasia related to Barrett's esophagus and endoscopic palliation of esophageal cancer.
Cancer Control. 2013;20(2):117-129.
9/18/2007 DynaMed's Systematic Literature Surveillance
http://www.ebscohost.com/dynamed: Küchler T, Bestmann B, Rappat S, Henne-Bruns D, Wood-Dauphinee S. Impact of psychotherapeutic support for patients with gastrointestinal cancer undergoing surgery: 10-year survival results of a randomized trial.
J Clin Oncol.
Last reviewed May 2016 by Michael Woods, MD
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Information Services. All rights reserved.