WEDNESDAY, Sept. 8 (HealthDay News) -- The exact cause of type 1
diabetes is still unknown, but international researchers have found
a link between the blood sugar disorder and a network of immune
Using a genome-wide association study, the researchers found
that a certain group of genes that react in response to viral
infections were present in both rats and humans, and that those
same genes were also associated with a susceptibility to type 1
"Diseases arise as a result of many genetic and environmental factors through gene networks that cause tissue damage," explained study senior author Dr. Stuart Cook, the group head of molecular and cellular cardiology at the Medical Research Council Clinical Sciences Centre, and a professor of clinical and molecular cardiology at Imperial College in London.
"We used an approach to identify the major control points' central command of an inflammatory gene network. This led us to uncover hundreds of new genes that might cause diabetes and one major control gene that controls the whole network," said Cook.
He added that one of the genes belongs to a class of genes that
might make a good target for drug therapy in the future.
Results of the study are published in the Sept. 9 issue of
Each year, more than 30,000 people are diagnosed with type 1
diabetes, formerly known as juvenile diabetes, according to the
Juvenile Diabetes Research Foundation (JDRF). People with type 1
diabetes no longer produce enough of the hormone insulin to
effectively use the sugars found in carbohydrate-containing foods.
To survive, people with type 1 diabetes must take insulin
injections or use an insulin pump for the rest of their lives.
Experts believe the disease is an autoimmune disease, which
means that the body's immune system mistakenly turns against
healthy cells, such as the insulin-producing cells in the pancreas,
and destroys them. People who develop type 1 diabetes are believed
to have a genetic susceptibility to the disease that's then
triggered by something in the environment, possibly a virus.
In the current study, the researchers didn't initially set out
to look for type 1 diabetes genes. They started out by looking at a
certain group of genes in rats, in this case a network of genes
controlled by a gene called interferon regulatory factor 7 (IRF7).
IRF7 is like a master switch that controls the genes in its
network. The entire network of genes controlled by IRF7 is called
the IRF7-driven inflammatory network (IDIN).
The researchers discovered that when there were differences in
IRF7, there were also differences in the way other genes expressed
Cook and his colleagues then searched for a network of genes in
humans that might behave the same way. They found an area on
chromosome 13q32 that is controlled by a gene called the
"Epstein-Barr virus induced gene 2" (Ebi2). This gene appeared to
be the human equivalent of the IRF7 gene in rats.
Within this human version of the IDIN, research found a gene
called IFIH1, which has been found in other research to be
associated with the development of type 1 diabetes.
"Usually, research starts from the genetics and goes to function. Here, they started with a function -- [an immune system reaction] -- and were looking for a gene," explained Marie Nierras, director of research and scientific affairs for the JDRF.
"The value of such a result is that if you can get to the same place using more than one pathway, it tends to support the hypothesis," she said.
In this case, the hypothesis supported is the idea that type 1
diabetes may be triggered by an immune system response to a virus.
However, Nierras stressed that this study doesn't conclusively
prove that a virus is the trigger for type 1 diabetes.
"We know better today that this network of genes is involved, and with a network, you have many targets you can test. This research invites us to plan experiments going forward, and opens up many more questions, like 'If I disrupt this branch of the network, do I disrupt diabetes?' Or, 'If you look back at previous research knowing this study's results, does that help to better explain previous results?'" said Nierras.
Cook said this type of genome-wide association study can be used
for other diseases as well, and that his team is hoping to
eventually develop a new drug based on the genetic target they
Learn more about type 1 diabetes and its causes from the
U.S. National Library of Medicine.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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