FRIDAY, Sept. 10 (HealthDay News) --Some dieters may be more
likely than others to regain any excess pounds they've lost,
depending on their particular hormonal makeup, new Spanish research
A certain combination of appetite hormones leptin and ghrelin
appears to predispose some people to weight gain following a diet,
the researchers found.
Study author Ana Crujeiras, of Complejo Hospitalario
Universitario de Santiago in Spain, and her team report the finding
in an upcoming issue of the
Journal of Clinical Endocrinology & Metabolism.
The connection between appetite hormones such as ghrelin and
leptin and long-range weight-loss complications stems from work
with 104 obese and overweight men and women, all of whom embarked
on an eight-week, low-calorie diet.
Before dieting, during the diet, and about four months
post-diet, Crujeiras and her colleagues measured each participant's
body weight and fasting plasma levels of ghrelin, leptin and
The bottom-line: Those with higher leptin and lower ghrelin
levels before dieting were more likely to reacquire the lost weight
after the diet ended.
"We believe this research may indicate that the outcome of weight therapy may be pre-conditioned," Crujeiras said in a news release from the Endocrine Society.
"Our findings may provide endocrinology and nutrition professionals a tool to identify individuals in need of specialized weight-loss programs that first target appetite hormone levels before beginning conventional dietary treatment," she added.
And while noting that "the long-term success of maintaining the
weight lost is usually poor," Crujeiras suggested that the current
observations "could be used as a tool to personalize weight-loss
programs that could guarantee success in keeping off the
For more on appetite and digestion, visit the
National Institute of Diabetes and Digestive ...
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.