WEDNESDAY, Sept. 29 (HealthDay News) -- Using the
anti-inflammatory drug dexamethasone along with antibiotics
increases the chance of surviving a bout with bacterial meningitis,
Dutch researchers report.
"Dexamethasone therapy reduces mortality from bacterial meningitis by one-third," said lead researcher Dr. Diederik van de Beek, a clinical neurologist from the Academic Medical Center at the University of Amsterdam.
"That's a huge effect," he added. "Normally, the death rate of bacterial meningitis is 30 percent; if you use dexamethasone, it decreases to 20 percent."
The report is published in the Sept. 29 online edition and the
Oct. 26 print issue of
For the study, van de Beek's team collected data on 357 people
16 and older who had bacterial meningitis between 2006 and 2009. Of
these patients, 84 percent were given a dose of dexamethasone, a
corticosteroid, before antibiotic treatment was started.
The researchers compared the outcomes of these patients with 352
patients treated for bacterial meningitis between 1998 and 2002,
before dexamethasone was routinely given for the infection. Among
these patients, only 3 percent had been given dexamethasone, the
Deaths among those given dexamethasone in the 2006-2009 study
group were 10 percent lower than for those in the early study
group. In addition, hearing loss was almost 10 percent lower for
people in the 2006-2009 study group compared with the earlier
group, the investigators found.
"If you extrapolate these findings to the U.S., if you treat all patients with bacterial meningitis with dexamethasone, that would save one life every day," van de Beek said.
Guidelines in the United States recommend the use of
dexamethasone for suspected cases of bacterial meningitis, he
Jeffrey Cirillo, an associate professor of microbial and
molecular pathogenesis at Texas A&M Health Science Center
College of Medicine, said that the study's results confirmed
previous findings in clinical trials and laboratory models that
dexamethasone treatment in combination with antibiotics can reduce
mortality in patients.
"These results strongly support the use of dexamethasone in cases of pneumococcal meningitis and offer promise to improve the chances of survival from meningitis, a frequently deadly illness," Cirillo added.
Since 2000, a vaccine against bacterial meningitis has been
available. A study last year confirmed that the vaccine has
significantly cut the number of cases of the disease.
Overall, the number of cases of the disease dropped 30 percent
in that time, but the effect on the very youngest and oldest was
even more pronounced: Incidence decreased by 64 percent in those
younger than 2 and by 54 percent in those older than 65, according
to the report, published in the Jan. 15, 2009 issue of the
New England Journal of Medicine.
The vaccine, known as Prevnar and made by Wyeth Pharmaceuticals,
is part of the standard vaccination recommendation for children in
the United States ages 2 to 23 months, as well as for children 24
to 59 months old who are at high risk for pneumococcal disease.
Meningitis causes inflammation to the membranes in the brain and
spinal cord. Bacterial meningitis, unlike viral meningitis, can be
deadly and can also cause hearing loss, brain damage and learning
disabilities. The most common and severe form of bacterial
meningitis is pneumococcal meningitis. About 30 percent of people
with bacterial meningitis die from it, according to background
information provided in a news release from the American Academy of
For more information on bacterial meningitis, visit the
U.S. Centers for Disease Control and
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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