-- Alan Mozes
FRIDAY, Nov. 5 (HealthDay News) -- Over the past 10 years,
treatment options for patients with an inflammatory kidney disorder
known as lupus nephritis have vastly improved, according to a new
This means that patients with lupus nephritis, which is a
complication that can occur in individuals with the autoimmune
disease systemic lupus erythematosus (SLE), can now expect a better
quality of life, without many of the harsh treatment side
The review further indicates that new treatments for this
serious kidney disorder are already coming down the pike, and will
probably lead to even better options in the future.
"Treatment of lupus nephritis is rapidly changing, becoming safer and more effective," Dr. Gerald Appel, of Columbia University College of Physicians and Surgeons in New York City, said in an American Society of Nephrology news release.
Appel and Columbia colleague Dr. Andrew Bomback present their
findings in the Nov. 1 online edition of the
Journal of the American Society of Nephrology.
The authors noted that SLE affects about 1.4 million Americans,
mostly women between the ages of 20 and 40.
The current observations stem from a broad review of research
conducted over the past decade. Among the improvements in treatment
approaches the co-authors cited was the establishment of new
disease classification protocols; the advent of new and shorter
treatment regimens involving lower dosages of highly toxic
medications; and the emergence of less toxic drug alternatives.
The replacement of single drug interventions with combination
options have also led to better treatment outcomes, the authors
added, as have new therapies that carefully target certain parts of
the immune system. And for patients who enter remission, new
research has found that there are drug strategies that may help
keep them from relapsing.
"The treatment of lupus nephritis today is markedly different, and objectively more effective, than it was 10 years ago," the authors said in the news release. "The hope and expectation is that a similar claim will be made 10 years hence."
For more on lupus, visit the
U.S. National Institute of Diabetes and Digestive ...
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