-- Robert Preidt
MONDAY, Nov. 29 (HealthDay News) -- Women have worse outcomes
than men following surgery for peripheral arterial disease (PAD) in
their lower extremities, a new study has found.
Researchers reviewed data from 372,692 hospital admissions for
PAD surgery in lower extremities conducted from 1998 to 2007 in New
Jersey, New York and Florida. Of those hospitalizations, 162,730
(43.6 percent) were women.
The analysis showed that, following surgery, women were more
likely than men to die (5.26 percent versus 4.21 percent).
"The most pronounced difference was in cerebrovascular, where women had a 33 percent higher risk of [death] after adjustment for other relevant risk factors. In patients with underlying coronary artery disease, the risk in women was 21 percent higher," Dr. Ageliki G. Vouyouka, a vascular surgeon at Mount Sinai School of Medicine, said in a Society for Vascular Surgery news release.
Women were also more likely to suffer complications. For
example, rates of perioperative bleeding were 10.62 percent for
women and 8.19 percent for men. When they controlled for other
factors, the researchers determined that women were 33 percent more
likely to experience perioperative bleeding.
"Whether this is due to anatomic or technical factors in females, such as smaller arteries and use of relatively large devices during procedures, or excessive usage of blood thinners not adjusted to the women's weight and pharmacokinetics, further investigation using primary data collection is warranted on this subject," Vouyouka said.
Overall rates of perioperative infection were 3.23 percent for
women and 2.88 percent for men. Women were 21 percent more likely
to suffer an infection, calculated the researchers.
The study is published in the November issue of the
Journal of Vascular Surgery.
The U.S. National Heart, Lung, and Blood Institute has more
peripheral arterial disease.
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