-- Alan Mozes
TUESDAY, Dec. 21 (HealthDay News) -- For acute myeloid leukemia
patients, overactive genes in their leukemic stem cells (LSC) can
translate into a more difficult struggle to overcome their disease
and achieve prolonged remission, new research reveals.
"In many cancers, specific subpopulations of cells appear to be uniquely capable of initiating and maintaining tumors," the study authors explained in their report. The researchers identified 52 LSC genes that, when highly active, appear to prompt worse outcomes among acute myeloid leukemia (AML) patients.
The finding is reported in the Dec. 22/29 issue of the
Journal of the American Medical Association.
Between 2005 and 2007, study author Andrew J. Gentles, of
Stanford University in Palo Alto, Calif., and colleagues examined
gene activity in a group of AML patients as well as healthy
individuals. Separate data concerning AML tumors in four groups of
patients (totaling more than 1,000) was also analyzed.
In one of the patient groups, the investigators found that
higher activity levels among 52 LSC genes meant a 78 percent risk
of death within a three-year period. This compared with a 57
percent risk of death in the same time frame for AML patients with
lower gene activity among these specific "signature" genes.
In another AML patient group, the research team observed that
higher gene activity prompted an 81 percent risk for experiencing a
disease set-back over three years, compared with just a 48 percent
risk among patients with low gene activity.
What's more, Gentles and his colleagues found that higher
activity among these 52 LSC genes generally meant a poorer response
to chemotherapy treatment and lower remission rates.
The authors suggested that by "scoring" the activity levels of
these 52 genes from low to high, clinicians might be able to better
predict how well AML patients will respond to therapy. The finding
could also help advance the design of future studies that aim to
improve treatment strategies overall.
"Ultimately, this model has major implications for cancer therapy, most notably that in order to achieve cure, the cancer stem cells must be eliminated," the study authors said in a journal news release.
In the opinion of Dr. Nelson Chao, a professor of medicine and
immunology, as well as chief of the division of cellular therapy at
Duke University in Durham, N.C., the current work represents an
effort to craft a highly personalized approach to disease
"This is the holy grail of personalized medicine, which is to find an individual signature with a disease so that each patient is handled as an individual. Because not everyone who has AML has the same tumor," Chao explained.
"And there are two implications with this," Chao added. "One is the prediction part. If we can predict how a particular patient may fare with treatment we can, for example, decide that someone at very high risk may need more aggressive or more investigational type of approaches."
And, he noted, "The flip side of that is that if we can learn
what specific pathways are activated in a patient's leukemic stem
cells, then we could end up turning to drugs that might be quite
different from what we normally think of using today for AML. It
may mean we end up using different drugs that we aren't even
thinking of at this point. But of course, we have to look at this
as a long-term goal."
For more on myeloid leukemia treatment, visit the
U.S. National Cancer Institute.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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