TUESDAY, Jan. 11 (HealthDay News) -- Jane Adrian, 61, a
landscape architect in Glendale, Calif., saw her parents and two
co-workers suffer from the painful, blistering condition known as
shingles, so when the vaccine became available, she got it.
Even though the vaccine is only about 55 percent effective,
"it's better than nothing," she said. "Now I feel relieved."
A study of a cross-section of adults enrolled with a
health-management organization in southern California shows that
the vaccine provides protection for many older adults without many
The findings are published in the Jan. 12 issue of the
Journal of the American Medical Association.
Shingles is caused by the herpes zoster virus and only strikes
people who have had chicken pox. It usually starts as a rash on one
side of the face or body, often causing pain, itching and tingling.
About a million cases occur in the United States each year, and
attacks can last two to four weeks.
"Even after the rash has healed, the pain can last for months or even years," said lead study author HungFu Tseng, a research scientist at the Kaiser Permanente Division of Research and Evaluation in Pasadena, Calif.
Zostavax, as the vaccine is called, was approved in 2006, based
on the results of clinical trials. The U.S. Centers for Disease
Control and Prevention recommends the shot for eligible people aged
60 and older.
Tseng's team wanted to test the vaccine's real-world
performance, so they compared 75,761 vaccinated members of the
Kaiser Permanente health plan to 227,283 members who elected not to
have the shot. Kaiser funded the study.
In vaccinated individuals, the rate of shingles was 6.4 cases
per 1,000 people in a year while it was twice that -- 13 per 1,000
-- in the unvaccinated population, the investigators found.
The vaccine also reduced the risk of ophthalmic herpes zoster
(infection that affects the eye) by 63 percent and hospitalization
by 65 percent.
Those who had been vaccinated were more likely to be white,
female and in better overall health than the unvaccinated people,
the researchers noted. Lack of awareness, concerns about
effectiveness or safety, and cost may have kept some people from
getting the shot, Tseng said.
"People 60 and over can consider talking to their physician about the possibility of receiving the vaccine to reduce their risk, and the doctor can evaluate if they are eligible," said Tseng.
Patients with leukemia, lymphoma, HIV or an allergy to any
ingredients in the vaccine are ineligible for the shot.
"It does bolster our confidence that it's effective in the real world," said Dr. Bruce Hirsch, an attending physician in infectious diseases at North Shore University Hospital in Manhasset, N.Y., who was not involved with the study.
But the vaccine can cost a couple of hundred dollars, he said,
perhaps making it out of reach for those with limited
Because shingles is not contagious and doesn't present a risk of
death, Hirsch said he would recommend the flu vaccine and the
pneumococcal vaccine over this one for uninsured patients who would
have to pay out-of-pocket.
"This study helps me in terms of advising patients and prioritizing," Hirsch added.
While less reliable than some childhood vaccines, which are
usually 90 percent effective in preventing certain illnesses, the
shingles vaccination is still worthwhile, said Dr. Ciro Sumaya,
professor of health policy and management at Texas A&M Health
Science Center School of Rural Public Health.
"I think it's a very good vaccine, and it's a safe vaccine, but obviously there needs to be continuing surveillance of usage of the vaccine to make sure there are no adverse effects that are seen in one in a 100 million cases versus one in five or 10,000 people," said Sumaya, also a member of CDC's Advisory Committee on Immunization Practices.
For now, he advises getting it. "It's protecting against a
severe disease, particularly in elderly adults," he said, "so the
benefit, I think, is overwhelming that we should be using this
because it's recommended."
The CDC has more on the
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