-- Robert Preidt
WEDNESDAY, March 16 (HealthDay News) -- Artesunate should
replace quinine as the drug of choice for treating malaria,
according to an updated review of clinical trial results.
Derived from herbs used in Chinese medicine, artesunate was
found to be more effective at preventing death in people with
The review, published in the
Cochrane Library, includes the findings of a large study of African children published last year in The Lancet and eight other clinical trials, all together
involving 1,664 adults and 5,765 children from a number of areas in
Africa and Asia.
The updated review shows that using artesunate to treat people
with severe malaria reduces the risk for death by 39 percent in
adults and 24 percent in children, compared with quinine. In
adults, deaths fell from 241 per 1,000 with quinine to 147 with
artesunate. In children, deaths were reduced from 108 per 1,000
with quinine to 83 with artesunate.
Neurological problems were more common among children given
artesunate than among those who were given quinine, but most of the
problems were resolved within a month of treatment and were
outweighed by the increase in survival rates, the researchers
"The balance of benefits and harms is in favor of treatment with artesunate," David Sinclair, of the Liverpool School of Tropical Medicine in England, who led the review team, said in a Cochrane news release.
Peter Olumese, of the World Health Organization's Global Malaria
Program, said in the news release that sufficient evidence now
exists "to be confident of these results" and that "intravenous
artesunate is now being recommended as the treatment of choice for
adults and children with severe malaria anywhere in the world."
The U.S. Centers for Disease Control and Prevention has more
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