-- Randy Dotinga
FRIDAY, April 29 (HealthDay News) -- A new study in rats
suggests that coating stents with two chemicals found in red wine
may help them do a better job of propping open arteries after
Stents are designed to keep blood vessels open and unclogged,
and they now come coated with medications designed to prevent
clots. But the medications can cause problems in the vessels and
even lead to blood clots in rare cases.
Researchers from Louisiana State University coated stents with
two chemicals, resveratrol and quercetin, that are found in red
wine. They then inserted the stents into the arteries of rats.
The researchers found that the treated stents blocked the
narrowing of blood vessels and led to less inflammation in the four
weeks after they were inserted into the rats.
The study looks promising, said Alzheimer's disease researcher
Philippe Marambaud, who studies resveratrol. "There's overwhelming
evidence that this compound has very powerful properties," he said.
Marambaud is an assistant professor at the Feinstein Institute for
Medical Research in Manhasset, N.Y.
Dr. Gregg Fonarow, a professor and director of the Ahmanson-UCLA
Cardiomyopathy Center at the University of California, Los Angeles,
described the research as intriguing. But he cautioned that because
"this is a preliminary study in an animal model, much more research
and large-scale clinical trials would be needed" to determine
whether the coated stents have value as a treatment for people.
The study was to be presented Friday at an American Heart
Association conference in Chicago.
The U.S. National Heart, Lung, and Blood Institute has more on
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