-- Robert Preidt
TUESDAY, July 12 (HealthDay News) -- Using an invasive procedure
to diagnosis lung infections in infants with cystic fibrosis does
not improve their long-term outcomes, a new study finds.
Lung infections in children with cystic fibrosis are associated
with increased risk of illness and death.
Australian researchers examined the use of bronchoalveolar
lavage (BAL), an alternative diagnostic procedure used when young
children with CF can't provide sputum for analysis. BAL involves
inserting a bronchoscope through the nose or mouth to collect a
sample of fluid from the lungs.
The study found that the 79 infants with CF who were treated for
infection based on a diagnosis using BAL did not have a lower rate
of lung-damaging infection or structural lung injury by the time
they were 5 years old, compared with the 76 infants with CF who
were diagnosed with lung infections using the standard
The study appears in the July 13 issue of the
Journal of the American Medical Association.
"BAL-directed therapy provided no clinical, microbiologic or radiographic advantage, and led to an increased risk of predominantly mild adverse events as a direct result of bronchoscopy as well as disadvantages such as the need to fast prior to the procedure, exposure to anesthesia and potential perioperative anxiety," concluded Dr. Claire E. Wainwright, Royal Children's Hospital, University of Queensland, Brisbane, and colleagues.
The Cystic Fibrosis Foundation has more about
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