-- Robert Preidt
WEDNESDAY, July 27 (HealthDay News) -- Intensive
glucose-lowering treatment for people with type 2 diabetes doesn't
reduce the risk of cardiovascular-related death and doctors need to
be cautious about prescribing this type of treatment, a new study
Patients with type 2 diabetes are at increased risk for
cardiovascular disease. Intensive glucose-lowering treatment is
widely used for these patients even though previous research hasn't
shown any clear benefits, the researchers pointed out in a report
published in the July 27 online edition of the
In the new study, Catherine Cornu, a research physician at the
Clinical Investigation Centre, Louis Pradel Hospital in Bron,
France, and colleagues reviewed 13 studies that included a total of
34,533 diabetes patients -- 18,315 who underwent intensive
glucose-lowering treatment and 16,218 who received standard
Intensive treatment did not significantly reduce cardiovascular
death or all-cause death, but it was associated with a 15 percent
reduced risk of non-fatal heart attacks and a 10 percent reduced
risk of microalbuminuria, an indicator of kidney problems and heart
disease, the researchers found.
But, intensive treatment was also linked with a more than
twofold increase in the risk of dangerously low blood glucose
levels (severe hypoglycemia), the investigators noted in a journal
Over a five-year treatment period, 117 to 150 patients would
need to undergo intensive glucose-lowering treatment to prevent one
heart attack, 32 to 142 patients would have to be treated to
prevent one case of microalbuminuria, and 15 to 52 would need to be
treated to avoid one severe hypoglycemic event, the researchers
"Intensive glucose-lowering treatment of type 2 diabetes should be considered with caution and therapeutic escalation should be limited," the authors concluded.
The U.S. National Institute of Diabetes and Digestive and Kidney
Diseases has more about
type 2 diabetes.
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