TUESDAY, Nov. 22 (HealthDay News) -- For patients with a
condition called infective endocarditis, coupled with heart
failure, heart valve surgery can reduce the risk of dying by nearly
two-thirds, a new study suggests.
Infective endocarditis, an infection of the lining of the heart
that often includes the heart valves, has been associated with a
high risk of death. Previous studies have found that in-hospital
mortality can be as high as 20 percent and death after a year can
reach 40 percent.
"Cardiac surgery during hospitalization for infective endocarditis is associated with significantly lower in-hospital and one-year mortality, compared to medical therapy [drug therapy] alone, even for heart failure which is mild or moderate in severity," said lead researcher Dr. Andrew Wang, a cardiologist and associate professor of medicine at Duke University.
About one-third of patients with endocarditis experience heart
failure as a complication, which is typically advanced or severe in
degree and due to an acute heart valve problem, he said.
"Nearly two-thirds of patients with this complication undergo surgery during the initial hospitalization, and surgery is associated with lower mortality at one year," Wang added.
Patients with endocarditis and mild heart failure should be
evaluated by a team of specialists for possible cardiac surgery, he
noted. "Increased use of cardiac surgery for patients with this
complication may lower the mortality rate in endocarditis," Wang
The study was published in the Nov. 23/30 issue of the
Journal of the American Medical Association.
For the study, Wang's team looked at data from more than 4,000
patients with endocarditis of a heart valve from June 2000 to
December 2006, in 61 hospitals in 28 countries.
Among patients with chest X-rays available, 33 percent had heart
failure and 67 percent of these patients had heart failure so
severe it limited their activities.
More than 800 of these heart failure patients underwent heart
Wang's group found that nearly 30 percent of the heart failure
patients died in the hospital, and those who had surgery were at
lower risk (20.6 percent) compared with patients treated with drug
therapy alone (44.8 percent).
After one year, 29 percent of the patients who had surgery died,
compared with 58 percent of the patients who were on drug therapy
alone, the researchers found.
Factors connected with dying in the year after treatment
included older age, diabetes, an infection contracted in the
hospital, other infections, stroke and complications from the
surgery, the study authors noted.
In the United States, there are about 15,000 new cases of
infective endocarditis each year, according to background
information in the study.
Wang noted that the average Medicare payment to hospitals for
heart valve replacement surgery ranges from $25,000 to $45,000.
"In our study, surgery for patients with heart failure as a complication of endocarditis was associated with a 50 percent lower mortality, compared to medical treatment alone, so was more effective than medical therapy," he said.
Commenting on the study, Dr. Gregg Fonarow, a professor of
cardiology at the University of California, Los Angeles, and a
spokesman for the American Heart Association, said that "infective
endocarditis results in very substantial morbidity and
The risks these patients face are even higher if the infective
endocarditis results in heart failure. In these patients, the
benefits of valvular heart surgery generally outweigh the risk, he
"Current guidelines from the American Heart Association and American College of Cardiology recommend surgery in patients with endocarditis complicated by heart failure, even in older patients with multiple comorbid [pre-existing] conditions," Fonarow said.
"These findings suggest that there are further opportunities to improve the care of patients with infective endocarditis, both in identifying appropriate patients for surgery and improving outcomes for those treated surgically," he added.
For more on endocarditis, visit the
U.S. National Library of Medicine.
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