-- Robert Preidt
WEDNESDAY, Jan. 18 (HealthDay News) -- Smoking activates certain
genes and portions of the immune system, which in turn causes
inflammation that leads to emphysema.
So say researchers who mapped the destructive path from smoking
to the debilitating lung disease in mice.
"Previously, emphysema was thought to be a nonspecific injurious response to long-term smoke exposure," study author Dr. Farrah Kheradmand, a professor of medicine and immunology at Baylor College of Medicine, said in a college news release. "These studies show for the first time that emphysema is caused by a specific immune response induced by smoke."
She and her colleagues spent more than four years unraveling how
smoking leads to emphysema. They exposed mice to conditions that
closely simulated how humans smoke. The mice developed emphysema
within three to four months, and certain inflammatory cells and
genes were crucial in the process, Kheradmand said.
"It is a combination of little genes affected by an epigenetic factor," she said.
Epigenetic factors affect the way genes are expressed after DNA
forms, the release noted. One environmental epigenetic factor is
"DNA is written in pen. Epigenetics is written in pencil," Kheradmand said. "If you have enough genes affected by epigenetic factors strung together, it can tip you over into lung damage and emphysema. The inflammation that drives emphysema could also drive cancer development, a testable hypothesis that we have begun to pursue."
The findings appear online Jan. 18 in the journal
Science Translational Medicine.
While studies involving animals can be useful, they frequently
fail to produce similar results in humans.
The American Lung Association has more about
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