FRIDAY Dec. 28 (HealthDay News) -- Both sickle cell disease and
the condition known as sickle cell trait are genetic blood
diseases: You're born with one or the other because of the genes
inherited from your parents. Beyond that, the two conditions vary
Sickle cell disease gets its name from the shape of the red
blood cells in someone who has it. They're crescent-shaped, similar
to a farm tool called a sickle. These abnormally shaped red blood
cells become hard and sticky and can clog the blood vessels,
creating pain, according to the U.S. Centers for Disease Control
People with sickle cell disease are also prone to infections,
anemia and enlarged spleens, said Dr. Radhika Peddinti, a pediatric
hematologist at La Rabida Children's Hospital in Chicago. However,
the prognosis for people with sickle cell disease has improved
dramatically. "It used to be that the life expectancy for someone
with sickle cell disease was 20 or 25 years," she said. "Now people
are living with sickle cell disease, not dying from it. We're
getting at the complications early and managing sickle cell
To get sickle cell disease, you have to inherit a sickle cell
gene from each parent. Those who inherit a sickle cell gene from
one parent have the sickle cell trait. About 2 million people in
the United States have sickle cell trait, according to the CDC.
Most people with the trait have no signs or symptoms of sickle
cell disease. Such extreme conditions as high altitude or high
heat, however, can create an exception for someone with the sickle
cell trait who exercises intensively. In those conditions, their
red blood cells can change to a sickle shape and can block the
normal flow of blood to tissues and muscles. Though rare, this
could lead to an athlete collapsing and possibly dying, according
to the National Collegiate Athletic Association.
"In the U.S., a lot of the sickle cell trait we're seeing is not just in the African American population, but also in the Southeast Asian population, the Mediterranean population and in people coming from Jamaica," Peddinti said. "This is a worldwide disease."
Today, newborns are routinely screened for sickle cell disease
and sickle cell trait. Peddinti said that parents are always told
if a child has either and that the information should be passed on
to the child at some point. The knowledge becomes especially
important when people are going to have children of their own
because if two parents with the sickle cell trait have a child,
there's a 50 percent chance that their offspring will have sickle
A simple blood test can determine sickle cell trait status for
anyone who doesn't know it, and the test is available at most
hospitals, according to the CDC. Usually, a genetic counselor
explains the results, including what the implications for your
family might be.
For a look at the debate over sickle cell trait screening, click
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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