TUESDAY, Feb. 19 (HealthDay News) -- Modifying an infant's diet
to include the protein gluten while the mother is still
breast-feeding could lower the risk of celiac disease, a common
intestinal disorder, according to a new Swedish study.
That finding may sound counterintuitive, because celiac disease
is a condition in which the lining of the small intestine is
damaged by gluten-containing foods.
However, the researchers who conducted the study speculate that
there may be a window of opportunity in which an infant can develop
tolerance to the protein to possibly escape getting the
"We now have proven this way of introducing gluten reduces the risk of getting celiac disease," said Dr. Anneli Ivarsson, a pediatrician at Umea University in Umea, and lead author of the study published online Feb. 18 and in the March print issue of the journal Pediatrics.
Gluten refers to proteins found in specific grains, including
all forms of wheat and related grains such as barley and rye,
according to the Celiac Disease Foundation.
Celiac disease affects about 1 percent of the population,
according to Ivarsson. Genetic susceptibility plays a role. For
those affected, a life-long gluten-free diet is advised.
Ivarsson and her team compared two groups of Swedish children:
one born in 1993, during a time when the diagnosis of celiac
disease increased four-fold, and the other group born in 1997, when
it declined about the same amount. The children born later had a 25
percent lower risk of having celiac disease than those born
earlier, they found.
"That's quite a lot," Ivarsson said.
While 2.9 percent of those in the earlier born group had the
disease, 2.2 percent of those in the later-born group did.
The beginning and the end of the period in which the celiac
disease diagnoses rose were both marked by changes in recommended
feeding of infants, including the best age to introduce
gluten-containing foods, the researchers noted.
In 1982, experts recommended that gluten-containing foods not be
given until an infant was 6 months old. In 1996, the experts
recommended that gluten be introduced from 4 months on.
Experts know that a baby develops what they call oral tolerance
to an antigen (a substance that produces protective antibodies)
early in life. Celiac disease ''can be viewed as a failure to
develop oral tolerance to gluten, or a later loss of this
tolerance," Ivarsson wrote in her report.
In her study, babies born in the later group, who were
introduced to gluten-containing foods at 4 months on, were less
likely to develop celiac disease.
"We can't prove there is a window of opportunity" for developing tolerance, Ivarsson said, but that is one speculation.
The findings suggest -- but don't prove -- that gradually
introducing gluten-containing foods in small amounts from 4 months
of age, ideally while breast-feeding is ongoing, may protect
against celiac disease.
Why should breast-feeding go along with it? "Breast milk has
been shown to promote healthy bacteria in the gut," Ivarsson
If mothers can breast-feed, they should, she added. However,
genetic susceptibility also plays a role, she said, so a child
could still get celiac disease despite following the feeding
If a child does show symptoms, get early treatment, she said.
Symptoms include chronic diarrhea or constipation, abdominal
cramping and gas.
"This is actually what we have been advising" for feeding, said Dr. Peter Green, director of the Celiac Disease Center at the Columbia University Medical Center in New York City.
"We often get asked by people who are having a baby and there is celiac disease in their family, what could they do to reduce the risk of the baby getting celiac disease?" Green said. "We've actually been advising the parents to breast-feed and introduce a little gluten between 4 and 6 months." The recommendation is based on other research also finding that approach to be effective, he added.
The American Academy of Pediatrics has no official
recommendations about reducing celiac disease risk, but its experts
say that the risk of celiac disease is reduced 52 percent in
infants breast-fed at the time gluten is introduced.
To learn more about celiac disease, visit the
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