FRIDAY, May 31 (HealthDay News) -- Ritalin activates specific
areas of the brain in children with attention-deficit/hyperactivity
disorder (ADHD), mimicking the brain activity of children without
the condition, a new review says.
"This suggests that Ritalin does bring the brain [of a child with ADHD] back to the brain the typically developing kid has," said study author Constance Moore, associate director of the translational center for comparative neuroimaging at the University of Massachusetts Medical School.
Analyzing data from earlier studies that looked at how
children's brains were affected by doing certain tasks that are
sometimes challenging for kids with ADHD, the researchers found
that Ritalin (methylphenidate) was having a visible impact on three
areas of the brain known to be associated with ADHD: the cortex,
the cerebellum and the basal ganglia.
The study could be helpful in diagnosing and treating children
with ADHD, Moore said. "It may be helpful to know that in certain
children, Ritalin is having a physiological effect in the areas of
the brain involved with attention and impulse control," she
The research was published recently in the
Harvard Review of Psychiatry.
Nine studies analyzed by the researchers used functional MRI to
evaluate brain changes after children had taken a single dose of
Ritalin. The children were involved in different types of tasks
that tested their ability to focus and inhibit an impulse to
For example, to observe the brain's reaction during a test of
what is called "inhibitory control," a child was told that every
time he saw a zero show up on a screen, he should push the button
on the right; every time he saw an X appear, he should push the
left button. The children would then be asked to flip their
responses, pushing the left button when they saw a zero.
"That's hard to do," Moore said, "because you've developed the habit [of pushing the other button], so you have to suppress your impulse. If you do 20 zeros and keep pressing and then you see an X, most kids with ADHD will hit the wrong button."
In three out of five of the inhibitory control studies, Ritalin
at least partially normalized brain activation in ADHD
To note how the brain reacted to a selective attention test,
Moore said, children would first be asked, for example, what word
they were seeing. The word would be "red," and the color of the
type also would be red. Then they would be shown the word "red,"
but the color of the type would be green. In several studies,
Ritalin affected activation in the frontal lobes during such
inhibitory control tasks.
Most of the studies included in the review were performed in the
United States or the United Kingdom. The majority of participants
were adolescent boys, and all studies compared their results to
healthy children of the same approximate age.
Because none of the studies looked at the correlation between
ADHD symptoms and whether the child was taking Ritalin, there is no
way to link the changes in brain activation with clinical
improvement, Moore said. "It's possible that kids who are not
responsive to Ritalin may have brain changes too," she said.
ADHD affects between 3 percent and 7 percent of school-aged
children in the United States, according to the American
Psychiatric Association. Boys are more likely to have ADHD than
One expert was not surprised by the results.
"The review article shows there is a consensus of well-designed imaging studies showing that [Ritalin] has an impact on the frontal cortex of the brain, where we have long believed these patients have issues," said Dr. Andrew Adesman, chief of developmental and behavioral pediatrics at the Steven & Alexandra Cohen Children's Medical Center of New York, in New Hyde Park. Adesman wondered if Ritalin may play a role in helping the brain mature.
"Their data provides partial support for that," he said. "But if anything, the medicine seems to help the brain look more normal and doesn't seem to do anything bad to it."
Learn more about ADHD from the
Centers for Disease Control and Prevention.
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