-- Robert Preidt
MONDAY, July 15 (HealthDay News) -- U.S. National Cancer
Institute scientists have generated an extensive data set of
cancer-related genetic variations to help researchers better
understand how cancer responds to drugs and can resist
"To date, this is the largest database worldwide, containing 6 billion data points that connect drugs with genomic variants for the whole human genome across cell lines from nine tissues of origin, including breast, ovary, prostate, colon, lung, kidney, brain, blood and skin," said Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology.
"We are making this data set public for the greater community to use and analyze," Pommier said.
The research is published July 15 in the journal
Opening this data set to researchers will expand understanding
of the process by which normal cells are transformed into cancer,
Pommier said in a journal news release.
"This comes at a great time, because genomic medicine is becoming a reality, and I am very hopeful this valuable information will change the way we use drugs for precision medicine," Pommier said.
The researchers conducted whole-exome sequencing of the NCI-60
human cancer cell line panel, which is a collection of 60 human
cancer cell lines, and generated a comprehensive list of
cancer-specific genetic variations.
Preliminary studies conducted by the NCI team indicate that the
data set could dramatically improve understanding of the
relationships between specific cancer-related genetic variations
and drug response, which will accelerate the development of new
The NCI-60 human cancer cell line panel is used extensively by
cancer researchers to discover new anti-cancer drugs.
The U.S. National Cancer Institute has more about
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