MONDAY, Oct. 7 (HealthDay News) -- Delayed introduction of
gluten to a baby's diet and breast-feeding longer than one year
appear to increase the risk of celiac disease, researchers
People with celiac disease have an immune reaction to gluten, a
protein found in wheat, rye and barley. Over time, this abnormal
response can damage the small intestine and restrict nourishment,
affecting a child's growth and development.
"Avoidance of gluten as long as possible does not seem to be advisable," said lead researcher Dr. Ketil Stordal, a researcher and consultant pediatrician at the Norwegian Institute of Public Health in Oslo.
Late introduction of gluten -- after 6 months of age -- is
associated with a higher risk of celiac disease, and breast-feeding
does not reduce the risk, he added.
However, "we do not believe this indicates any disadvantages of
breast-feeding," Stordal said.
While the report, published online Oct. 7 in
Pediatrics, finds an association between prolonged
breast-feeding and delayed gluten introduction and celiac disease,
it does not establish a direct cause-and-effect relationship.
Randomized trials are still needed, Stordal said. If the
findings hold up, this could mean "there is an important time
window to start gluten introduction in small amounts between 4 and
6 months of age," he added.
Lara Field, a pediatric dietitian and nutrition advisor at the
University of Chicago Celiac Disease Center, said there is a lot of
discussion about when to start solid foods and how to prevent
celiac disease and food allergies.
"My recommendation is to start solids when the baby is developmentally ready," she said. This is when babies can sit up unassisted, prop themselves up on their elbows, and have lost their extrusion reflex -- tongue thrust out of the mouth. "This developmental readiness typically occurs between 4 and 6 months," she said.
The new information in this study is that breast-feeding past 12
months may increase risk for celiac disease, Field said.
"This is new data and perhaps the statistical power is too low to prove this theory," she added.
Field said she routinely suggests exclusive breast-feeding until
6 months, and then gradually decreasing breast milk as solid foods
are increased up to 1 year. This is in line with recommendations
from the American Academy of Pediatrics. At 1 year of age, she
suggests transitioning to cow's milk or an alternative, such as
almond, coconut, hemp or soy beverages.
At least one expert remains unconvinced that the timing of
gluten introduction or prolonged breast-feeding plays a role in the
development of celiac disease.
"If you have the genetic makeup for celiac disease and you are introduced to gluten at any time, you are going to get the disease," said Dr. William Muinos, co-director of pediatric gastroenterology at Miami Children's Hospital in Florida.
"That's what we have to focus on -- the genetic makeup of these patients and not whether they get introduced to gluten early or late, or if breast-feeding, that's not the issue," Muinos added.
About one in 133 Americans has celiac disease, according to the
National Digestive Diseases Information Clearinghouse. It is much
more common among children who have a parent or sibling with the
disease. Besides foods, gluten is found in many everyday products
such as vitamins and supplements, medicines, lip balm and the glue
on stamps and envelopes.
For the study, Stordal's team collected data on 107,000 children
in the Norwegian Patient Register. The introduction of gluten was
reported during the infant's first 6 months of life and
breast-feeding was reported during the first 18 months.
Among the nearly 82,200 children in the final analysis, 324
developed celiac disease. In 8 percent of those cases, infants
started eating foods with gluten before or at 4 months of age. In
45 percent of cases, gluten was introduced between 5 and 6 months
of age, whereas nearly 47 percent of those who developed celiac
disease first started eating foods with gluten after 6 months.
The risk for celiac disease was increased 27 percent when gluten
was introduced late, the researchers noted.
And breast-feeding after a year was associated with a 49 percent
increase in the risk for celiac disease, the study authors
For more information on celiac disease, visit the
U.S. National Library of Medicine.
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