MONDAY, Oct. 21 (HealthDay News) -- There's new hope for anyone
who's bald or balding: Researchers report they're getting closer to
the goal of cloning hair cells and coaxing them to grow hair once
they're replanted in the scalp.
"We've been able to overcome the first block," said study co-author Angela Christiano, a professor of dermatology and genetics & development at the Center for Human Genetics at Columbia University's College of Physicians & Surgeons in New York City.
For now, the research is in the early stages. Questions about
costs and possible side effects remain unanswered, and it's not
clear whether the technique will produce the kind of hair that
people want in terms of traits like texture.
At issue is the need for a better way to replace hair in people
who lose it, including an estimated 50 percent of people over the
age of 50 who suffer from hair loss.
There are drugs to help people with hair loss, but they tend to
focus on stimulating existing hair follicles to grow longer hairs,
Christiano explained. In male-pattern baldness, men still have
follicles that grow hair, but they produce "peach fuzz" instead of
There are other treatment options, but they're not much better,
one expert added.
"Surgical methods, mainly hair transplants, really just shuffle existing hair around from [the] back of scalp to front of scalp," said Dr. Luis Garza, an assistant professor at Johns Hopkins School of Medicine in Baltimore. "The main challenge is to grow a new hair follicle."
This new approach may also help more than just men with hair
"About 90 percent of women with hair loss are not strong candidates for hair transplantation surgery because of insufficient donor hair," Christiano said in a university news release. "This method offers the possibility of inducing large numbers of hair follicles or rejuvenating existing hair follicles, starting with cells grown from just a few hundred donor hairs. It could make hair transplantation available to individuals with a limited number of follicles, including those with female-pattern hair loss, scarring alopecia and hair loss due to burns."
In the new study, Christiano and her colleagues sought to figure
out how to take hair cells from the body, clone them and then
reinsert them back into the body where they'll grow new hair from
new follicles. The process falls apart because the cells lose the
ability to instruct the skin to make new hair, she explained.
In the new study, researchers found that the cells retain their
ability to figure out what to do when the researchers grow the
cells upside down. "We don't put genes into them, and they're not
manipulated at all," Christiano noted.
The hair cells produced by the process were able to produce new
hair in five out of seven donor models of human skin, she said,
although there's more work to be done to make them fully develop
hair the way they should.
The technique holds potential for more than cosmetic treatments
to help people grow new hair. Among other things, the research
could ultimately lead to more functional replacement skin for
people with scars and burns because the skin would have hair,
Garza praised the research, but emphasized that it is
preliminary. "This work helps to climb the mountain, but there are
miles to go and more steep terrain ahead," he said.
The study appears online Oct. 21 in the
Proceedings of the National Academy of Sciences.
For more about
hair loss, try the American Academy of Dermatology.
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