THURSDAY, Oct. 24 (HealthDay News) -- Men who undergo a biopsy
that rules out prostate cancer might still experience severe
anxiety because the procedure can result in pain or bleeding,
researchers have found.
The findings add to growing criticism of prostate cancer
screening using the prostate-specific antigen (PSA) test. Critics
say the test is unnecessary and potentially harmful, given that
many men with the cancer will have a slow-growing form of the
disease that may never prove fatal.
The results of a PSA test often are followed by biopsy. In the
new study, even those men who received a negative biopsy report
often felt alarm or worry due to pain at the incision site or blood
in their urine, stool or ejaculate, the British researchers
reported in the
Journal of Clinical Oncology.
Dr. Durado Brooks, director of prostate and colorectal cancers
for the American Cancer Society, said the research highlights
"This does give one more reason why doctors should be upfront with their patients talking about the whole process of prostate cancer detection," Brooks said. "If they choose to undergo a PSA test and it comes back high, they will have to have a biopsy. They may have a number of negative consequences from the biopsy even if they don't have a cancer diagnosis. This is a conversation that should take place before the first PSA level is drawn."
Prostate cancer is the most commonly diagnosed cancer in the
United States, and its incidence has risen rapidly following the
introduction of PSA blood tests, the researchers said in background
The influential U.S. Preventive Services Task Force, however,
recently recommended against PSA screening for men at average risk
for prostate cancer, concluding that it has little to no effect on
prostate cancer deaths but can cause great emotional and physical
harm to men who undergo treatment due to their test results.
"We think that men should have as much information as possible about the possible consequences of having a PSA test before they decide to take the test," said study co-author Jenny Donovan, a professor of social medicine at the University of Bristol.
"Most men having a PSA test will hope that it is negative, but it is important that they know that if the PSA is raised, they will be advised to have a prostate biopsy," Donovan said. "The biopsy process is uncomfortable for most, and for some will be painful and lead to symptoms including bleeding and infection, and, if the symptoms are severe, will lead to anxiety."
The study tracked more than 1,100 British men who underwent a
biopsy for prostate cancer. They returned questionnaires assessing
their anxiety and depression at the time of their biopsy, and at
seven days and 35 days following the procedure.
Men who reported biopsy symptoms as a moderate or major problem
a week after the procedure had markedly higher levels of anxiety
than those reporting biopsy symptoms as a slight problem or no
problem at all, the researchers said.
For example, 10 percent of men who had blood in their ejaculate
and considered it a serious problem experienced heightened anxiety,
compared with about 3 percent who had the same symptom but did not
consider it much of a problem.
This anxiety decreased over time, however. By 35 days after the
biopsy, the proportion of men with troubling biopsy-related
symptoms remained about the same, but they reported considerably
reduced levels of anxiety.
These results should give doctors pause before recommending a
PSA test to a patient, or ordering one on their behalf, cancer
"One of the major debates in American health right now is whether men should be screened for prostate cancer, because screening can lead to unnecessary biopsies," said Dr. Charles Ryan, a genitourinary cancer specialist with the University of California, San Francisco. "This article should be read by both urologists and primary-care physicians who should weigh this in their decision-making related to prostate cancer screening."
Despite current guidelines, however, many U.S. physicians still
routinely order PSA tests for patients. For example, a study in the
Oct. 16 issue of the
Journal of the American Medical Associationfound that
doctors surveyed in the study ordered PSA tests for 40 percent of
their male patients older than 75 -- even though no major medical
group recommends prostate screening for that age group.
Brooks, of the American Cancer Society, said that in the past,
doctors have tended to automatically order a PSA screening whenever
blood work is performed on a man, often without even discussing
with the patient what might happen if the test comes back
"It does them a real disservice if you haven't had a discussion with them about whether they want to head down that particular path," he said.
For more information on prostate cancer, visit the
U.S. National Cancer Institute.
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