MONDAY, Jan. 13, 2014 (HealthDay News) -- Drinking green tea may
lessen the effects of the medication nadolol (Corgard), used to
treat high blood pressure, a new small study suggests.
Researchers gave 10 volunteers a single dose of 30 milligrams of
nadolol after they had consumed either water or about three cups of
green tea daily for 14 days.
When researchers tested blood levels of the drug, they were 76
percent lower in the group that drank green tea compared to the
According to study's authors, that means that "patients treated
with nadolol should avoid taking green tea." They published the
findings online Jan. 13 in
Clinical Pharmacology & Therapeutics,
The researchers include Shingen Misaka at Fukushima Medical
University in Japan and other universities in Germany, Japan and
"Individuals who take nadolol and also consume green tea should be aware of this potential interaction and discuss this with their physician," advised Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, and a spokesman for the American Heart Association. He reviewed the findings but did not take part in the study.
Nadolol isn't the only drug that interacts with food or
beverages. For instance, grapefruit and grapefruit juices can
interact with medicines, such as cholesterol-lowering medicines and
some blood pressure drugs, according to the U.S. Food and Drug
Researchers for the new study say ingredients in the green tea
are thought to interfere with the absorption of the medication in
Nadolol is a type of blood pressure lowering drug known as a
beta blocker, used to treat both high blood pressure and angina,
the chest pain associated with heart disease.
Beta blockers, in general, work by reducing the heart rate and
the heart's workload and reducing the output of blood, thus
lowering pressure, according to the American Heart Association.
In the United States, nadolol is used less frequently than other
beta blockers, Fonarow said.
"It's not a commonly used beta blocker," agreed Dr. Suzanne Steinbaum, a cardiologist and director of women's heart health at Lenox Hill Hospital, in New York City, and a spokeswoman for the American Heart Association's Go Red for Women campaign.
Among the new study's limitations are the small number of
patients included, just 10, Steinbaum said. And she believes that
amount of tea consumed would be unusual, at least in the United
States. "It is rare to see a patient who drinks more than two cups
of green tea a day," she said of her own patients.
Fonarow said that the results may apply only to green tea and
nadolol. "It is not clear that those receiving other heart
medications and drinking green tea need to be concerned, or that
these findings apply to black tea," he said.
Also, athough the study showed reduced levels of nadolol in
patients who drank green tea, it could not establish a
cause-and-effect relationship. The researchers note that larger
studies are needed to understand how green tea may react with drugs
The study was funded by partially by the Japanese Ministry of
Education, Culture, Sports, Science and Technology.
To learn more about different blood pressure medicines, see the
American Heart Association.
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