-- Robert Preidt
WEDNESDAY, March 19, 2014 (HealthDay News) -- Among people with
hepatitis C, the risk of serious liver disease is much higher in
those who also have HIV than in those without the AIDS-causing
virus, a new study finds.
This is true even among patients with HIV who are otherwise
benefiting from antiretroviral therapy to treat the virus, the
University of Pennsylvania researchers said.
They analyzed data from more than 4,200 patients with both
hepatitis C and HIV who were receiving antiretroviral therapy. In
addition, they looked at data on more than 6,000 patients with
hepatitis C only. The patients received care between 1997 and
The HIV/hepatitis C patients had an 80 percent higher rate of
serious liver disease than those with hepatitis C only, according
to the study, which was published in the March 18 issue of the
Annals of Internal Medicine.
Even HIV/hepatitis C patients who had a good response to
antiretroviral therapy for HIV still had a 60 percent higher rate
of serious liver disease than those with hepatitis C alone.
Serious liver diseases were higher among HIV/hepatitis C
patients with advanced liver fibrosis, diabetes and severe anemia,
and among those who weren't black, the study also found.
"Our results suggest that serious consideration should be given to initiating hepatitis C treatment in patients co-infected with HIV and hepatitis C -- particularly among those with advanced liver fibrosis or cirrhosis -- in order to try to reduce the risk of serious, potentially life-threatening liver complications," study lead author Dr. Vincent Lo Re III, said in a university news release.
Lo Re is an assistant professor of medicine and epidemiology in
the university's division of infectious diseases and the department
of biostatistics and epidemiology, as well as an investigator at
the Penn Center for AIDS Research.
"By taking action sooner, we may be able to reduce the risk of advanced liver disease in co-infected patients," Lo Re added.
About 20 percent to 30 percent of HIV patients also have
hepatitis C, likely due to shared causes of infection.
AIDS.gov has more about
HIV and hepatitis.
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