FRIDAY, May 16, 2014 (HealthDay News) -- Men rendered infertile
due to defects in their semen and sperm are more likely to die
early than men with normal semen, new research suggests.
Over a period of about eight years, men with two or more
abnormalities in their semen had a risk of death that was more than
double that of men with healthy semen, researchers reported in the
May 16 online issue of
Knowing this, doctors who treat men for infertility should
advise them to adopt healthy habits that might boost their
survival, said lead author Dr. Michael Eisenberg, assistant
professor of urology and Stanford University School of Medicine's
director of male reproductive medicine and surgery.
"There may be a window of opportunity here. When they see their doctor they could do some other things that might benefit them," Eisenberg said. "I see this as an opportunity to pay more attention to your health and be more proactive."
For the study, Eisenberg and his colleagues reviewed the medical
records of about 12,000 men aged 20 to 50 who had visited either
the Stanford University School of Medicine or the Baylor College of
Medicine in Houston to be evaluated for possible infertility.
At both clinics, doctors had recorded information on patients'
semen quality, such as total semen volume, sperm counts, sperm
movement and shape. The researchers compared patient data with
death records to track the men's death rates, while taking into
account for underlying health issues that could compromise semen
While no single semen abnormality in itself predicted early
death, men with two or more such abnormalities had 2.3 times the
risk of death during the study period than those with no semen
abnormalities. The greater the number of abnormalities, the higher
the risk of death, the study found.
Low semen volume, sperm concentration, sperm activity, total
sperm count and the total count of active sperm specifically were
associated with a higher risk. Abnormally shaped sperm did not
appear to be linked to increased risk of death during the study
"This striking increased death rate in men with abnormal semen parameters highlights the urgency and need to investigate the causes of male infertility and not to just proceed with assisted reproductive technologies," said Dr. Natan Bar-Chama, director of male reproductive medicine and surgery at the Icahn School of Medicine at Mount Sinai in New York City.
Bar-Chama, who was not involved with the study, added that "it
is equally important to identify potential modifiable causes of
male infertility that could be acted upon and subsequently decrease
this increased mortality rate."
It's important to keep in mind that this study wasn't designed
to prove that semen abnormalities lead to a higher rate of death,
only to show there is an association between these factors.
However, the researchers have a number of theories as to why
poor semen quality might be linked to premature death risk,
For example, reproduction is an essential human activity, with
10 percent to 15 percent of the male genome dedicated to
propagation. "It's very easy to figure if you can't make sperm,
there are probably other things your body can't do well," he
Sperm defects also could be caused by low levels of
testosterone, an important male hormone that has been linked to
longevity, Eisenberg noted.
And, Eisenberg added, social factors associated with fertility
should not be ruled out. "If you look at studies, men who have
children enjoy extended life and lower mortality," he said.
Women who are infertile likely face a similarly increased risk
of death, he suggested, although this study only evaluated men.
"My belief is that infertility provides a window into a man's later health, and I think it would apply to both sexes," Eisenberg said. "We can expect to see the same effects in women as well."
For more about male infertility, visit the
U.S. National Library of Medicine.
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