To compare the efficacy of an investigational therapy when combined with standard therapy versus standard therapy alone, when looking at progression-free survival.
To better understand the clinical effectiveness of therapies used in treating relapsed/refractory multiple myeloma (MM) in the real-world clinical practice.
To describe current and evolving patterns for diagnosis, treatment, clinical monitoring and outcome measures in patients with low-risk or high-risk MDS, MDS risk not determined, and AML. To compare routine clinical practice patterns with existing management guidelines. To describe treatment patterns & outcomes in patients with cytogenetic abnormalities. To summarize patient-reported outcomes, economic outcomes, and their association with patient characteristics, treatment regimens, and clinical outcomes.
To compare the efficacy of 2 different treatments in patients with Chronic Phase CML as measured by major molecular response (MMR) rate at 12 months.
To describe the clinical burden, healthcare resource utilization, complications, practice patterns, and therapy strategies in patients treated for PV in academic & community clinical practices within the United States.
To estimate the relationship between chemotherapy & survival
To test two different dose levels in patients with squamous cell carcinoma of the head and neck who will receive treatment with chemotherapy & radiation therapy and may develop oral Mucositis as a result of the Chemoradiation therapy.
To demonstrate the overall survival of subjects receiving a single agent for Chemo-Induced Anemia in Stage IV Non-small Cell Lung Cancer patients.
To compare progression-free survival, overall response between two single-agent therapies in patients with indolent NHL that has relapsed.
To assess the efficacy and safety of iron chelation therapy with a single agent compared to placebo in patients with myelodysplastic syndromes (MDS) (low/int-1 risk) and transfusional iron overload.
To determine factors associated with prophylactic pegfilgrastim administration from the community oncology setting.
To compare the oncologic outcomes (local control, regional control, distant control, disease-free survival, cause-specific survival, overall survival) and rate of toxicities (frequency of symptoms) for patients diagnosed with a cancer in the chest or female reproductive tract.
To compare the effects of performing a standard lymph node removal versus an extended lymph node removal.
To test the safety & effectiveness of an investigational compound to determine if weekly doses can be safely administered to reduce the incidence (occurrence of), duration (length of time) and severity (amount of pain) of oral mucositis (painful sores in the mouth) in patients with advanced head & neck cancer receiving radiation and chemotherapy.