TUESDAY, Nov. 16 (HealthDay News) -- Stem cells taken from the
belly fat of 10 heart attack patients managed to improve several
measures of heart function, Dutch researchers report.
This is the first time this type of therapy has been used in
humans, said the scientists, who presented their findings Tuesday
at the American Heart Association's annual meeting in Chicago.
But the improvements, though relatively dramatic in this small
group of patients, were not statistically significant, probably due
to the limited number of participants in the study. And another
expert urged caution when interpreting the results.
"The key issue is whether a treatment makes us live longer or feel better," said Dr. Jeffrey S. Borer, chair of the department of medicine and of cardiovascular medicine at the State University of New York (SUNY) Downstate Medical Center in New York City.
This study only looked at "surrogates," meaning measures of
heart function that might predict better future health in the
patient, he said.
"This cannot be interpreted as if they directly represent positive clinical outcomes," Borer said. "These certainly are promising stem cell data, but there's a great deal more to do before it is possible to know whether this is a viable therapy."
Another caveat: All the patients in this trial were white
Europeans. The study authors believe the results could be
extrapolated to much of the U.S. population, but not necessarily to
people who aren't white.
Fat tissue yields many more stem cells than bone marrow (which
has been studied before) and is much easier to access.
In bone marrow, 40 cubic centimeters (cc) typically yield about
25,000 stem cells, which is "not nearly enough to treat people
with," said study author Dr. Eric Duckers, head of the Molecular
Cardiology Laboratory at Thoraxcenter, Erasmus University Medical
Center in Rotterdam. To get enough cells to work with, those stem
cells would have to be cultured, a process that can take six to
eight weeks, he said.
By contrast, 100 cc's of fat tissue yield millions of stem
cells, plenty to work with. A hundred cc's is about the size of a
coffee cup -- a European coffee cup, not the mega-size of American
coffee containers, Duckers emphasized.
"With that many cells, you can isolate them and give them to the patient right away as they come into the hospital," he explained.
All patients in this double-blind, placebo-controlled study (11
men and three women) arrived at the hospital having suffered a
severe heart attack. All then underwent cardiac catheterization to
assess blood flow, followed by percutaneous coronary intervention
(PCI), more commonly known as angioplasty, to restore blood
Within 24 hours of the heart attack, doctors performed
liposuction to remove fat tissue, isolated 20 million stem cells
and gave them back to the patients through a catheter. The infusion
took no more than 10 minutes. Ten patients received stem cells and
four received a placebo infusion.
"It was done very, very quickly, all in the same day," Duckers said.
Six months after the procedure, stem cell patients had better
blood flow (more than triple the rate compared to patients getting
a placebo), a 5.7 percent increase in heart pumping ability, and a
50 percent reduction in scarring of heart muscle (from 31.6 percent
right after the heart attack to 15.4 percent). Placebo patients saw
no decrease in scarring.
"In theory," Borer said, "the use of stem cells to improve myocardial perfusion [blood flow] and cardiac performance is very promising... but to the present time, although many approaches to stem cell use have been tested, there really has not yet been evidence of a clinically useful important result. That doesn't mean that stem cell research isn't an important lead to follow."
The Dutch research team is now embarking on a trial that will
ultimately enroll 375 heart attack patients at 35 medical centers
in the European Union to further test stem cell infusions.
The study was funded by Cytori Therapeutics Inc.
Institutes of Health has more on stem cells.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.