-- Robert Preidt
FRIDAY, April 22 (HealthDay News) -- Brain cancer patients live
longer if neurological side effects from chemoradiation can be
minimized, a new study says.
U.S. researchers analyzed the records of 2,761 patients with
high-grade gliomas -- the most common primary brain tumor -- who
were enrolled in 14 Radiation Therapy Oncology Group studies
between 1983 and 2003.
Patients who didn't experience neurological side effects, such
as fatigue and memory loss, during chemoradiation lived an average
of four months longer than those who had such effects, said the
team at the Kimmel Cancer Center at Thomas Jefferson University in
Chemoradiation involves giving patients chemotherapy and
radiation treatments together.
Side effects were most likely to occur in patients who were
older, frailer, had more symptoms and were receiving radiation
twice a day.
The researchers said their findings suggest that damage to
normal tissue during chemoradiation plays an important role in
determining long-term survival and that minimizing side effects
could benefit patients.
"Our results support the personalized approach to brain tumor management . . . and emphasize the importance of minimizing side effects," Yaacov Richard Lawrence, an assistant professor in the radiation oncology department at Thomas Jefferson University and director of the Center for Translational Research in Radiation Oncology at Sheba Medical Center in Israel, said in a university news release.
The study is published in the April issue of the
British Journal of Cancer.
The U.S. National Cancer Institute has more about
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