WEDNESDAY, Aug. 3 (HealthDay News) -- A new experimental drug
for adults with asthma seems to improve lung function in patients
who haven't been helped with standard steroids.
The drug, lebrikizumab, targets a specific receptor involved in
asthma, and appears to be the first drug to be successful in this
particular approach, said Dr. Steve Georas, a professor of medicine
in the pulmonary and critical care division at the University of
Rochester Medical Center.
It is also perhaps the first drug to have this specific effect
in asthmatics, and may lead to more gains in individualized
treatments for patients.
"Personalized medicine hasn't made huge strides in asthma," said Georas. "We're all hopeful we're on the verge of a new era in that regard. This appears to be a first tentative step in that direction."
Georas was not involved with the new research, which appears in
the Aug. 3 issue of the
New England Journal of Medicine and was funded by Genentech,
which makes lebrikizumab.
Lebrikizumab is a monoclonal antibody that binds to
interleukin-13 (IL-13), a signaling molecule involved in the
inflammatory responses associated with asthma.
Although glucocorticoids also inhibit IL-13, the molecule
manages to exert its influence in other ways which, so far, have
eluded current medications. But, lebrikizumab works in a different
way than traditional steroids.
The authors randomized 219 adults who had not responded to
standard treatments to receive either lebrikizumab or a
After three months, the overall group of patients taking
lebrikizumab saw a 5.5 percent improvement in their FEV1 (forced
expiratory volume in one second), which measures how much a person
expels when exhaling, compared to the placebo group.
Patients who had high IL-13 levels (as measured by the protein
periostin, which is produced by IL-13) saw an FEV1 improvement of
8.2 percent with lebrikizumab versus the placebo.
By contrast, in the low-periostin group, the improvement was
only 1.6 percent higher.
While overall side effects were roughly the same in both groups,
there were more musculoskeletal effects in the lebrikizumab group
(13.2 percent in the treatment arm versus 5.4 percent in the
In addition to the fact that the drug is not yet approved,
lebrikizumab may have other issues.
For one thing, it's not clear if clinics can easily measure
levels of periostin, said Georas. That would be key in determining
who would and who wouldn't benefit from the drug.
Also, lebrikizumab is given as an injection once a month,
something that many patients are reluctant to do. Even inhaled
medications -- especially glucocorticoids which can take days or
weeks to help -- aren't overly popular with patients, said Dr.
Susanna Von Essen, a professor of pulmonary and critical care
medicine at the University of Nebraska Medical Center in Omaha.
"People like pills better than inhaled medications and usually injections are down the list but, if it causes improvement, you will find some patients who will accept it," she said.
Also, this breaks new ground in blocking IL-13 so "maybe this
will be the beginning of a series of medications that attack the
IL-13 molecule and maybe they'll come up with something inhaled or
something you can swallow," she said.
American Lung Association has more on asthma.
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