MONDAY, Nov. 21 (HealthDay News) -- People with early evidence
of Alzheimer's disease are more likely to be underweight than
people who don't have this type of dementia, a new study
"Weight loss may be a manifestation of the disease process progressing," said Eric Vidoni, lead author of a study appearing in the Nov. 22 issue of Neurology. "This may be further evidence for body-wide or systemic changes associated with Alzheimer's disease ... and it certainly supports the idea that Alzheimer's disease-related changes could be silently occurring, i.e., a 'preclinical' phase."
The findings may hold implications for diagnosis, prevention or
treatment, but these are likely to be years or even decades
"A long history of declining weight or BMI (body mass index, a ratio of weight to height) could aid the diagnostic process," said Vidoni, who is assistant director of the University of Kansas Alzheimer's Disease Center in Kansas CityIs.
At this point, though, it's too early "to make body composition
part of the diagnostic toolbox," he added.
"If weight loss is part of the disease process, this could suggest, along with the many papers linking metabolic dysfunction with AD, that preventing such dysfunction could reduce the progression of AD," said Ian Murray, an assistant professor of neuroscience and experimental therapeutics at the Texas A&M Health Science Center College of Medicine. "Of course this is, at present, speculative."
Previous studies have found that people who are overweight in
middle age or earlier have a higher risk of developing Alzheimer's.
And those who are overweight in their later years actually may have
a lower risk of Alzheimer's, something known as the "obesity
Vidoni and his partners looked at PET (positron emission
tomography) imaging of the brain and analyzed cerebrospinal fluid
for markers of Alzheimer's disease in 506 people. Participants
represented a range of cognitive function, some with no memory
problems, some with mild cognitive impairment and some with
People with evidence of Alzheimer's -- either in brain scans or
protein levels in the cerebrospinal fluid -- were more likely to
have a lower BMI than those who did not show early evidence of the
And the markers of brain changes for Alzheimer's were most
evident in people with normal memory functioning or mild cognitive
impairment, although it's not clear yet why this is.
There are a number of theories -- but only theories at this
point -- to explain the findings.
One is that the Alzheimer's disease process is affecting the
hippocampus, that part of the brain involved in metabolism and
Or inflammatory processes may be driving both the decreased BMI
and the cognitive changes.
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