-- Robert Preidt
MONDAY, Jan. 9 (HealthDay News) -- Combination drug treatment
that targets estrogen production significantly reduced the number
of tobacco carcinogen-related lung tumors in mice, a new study
"Anti-estrogens have been shown to prevent breast cancer in some women," Jill Siegfried, a professor in the department of pharmacology and chemical biology at the University of Pittsburgh Cancer Institute, said in an American Association for Cancer Research news release.
"If anti-estrogens can prevent lung cancer as well, this would be a major advance, because these drugs are safe to give for long periods and there are no approved ways to prevent lung cancer," she added.
Most lung cancers have a type of estrogen receptor that makes
tumors grow when they're exposed to estrogen. In addition,
aromatase, an enzyme in the lung, produces estrogen.
Siegfried and her team found that blocking this estrogen
receptor and the aromatase enzyme could prevent estrogen-sensitive
lung tumors in mice exposed to a tobacco carcinogen.
The study was to be presented Monday at an AACR-International
Association for the Study of Lung Cancer joint conference on lung
cancer, held in San Diego. With research presented at a medical
meeting, the data and conclusions should be viewed as preliminary
until published in a peer-reviewed journal.
The findings may eventually lead to a treatment that could
greatly reduce ex-smokers' risk of lung cancer, according to
"We may be able to prevent lung cancer in people who have been previously exposed to tobacco carcinogens using some of the same anti-estrogen drugs that can prevent breast cancer," she said. "A lot of work needs to be done to determine who would benefit from this therapy, and these drugs would need to be tested in clinical trials in those at high risk for lung cancer."
While the findings of the new study appear promising, scientists
note that research involving animals often fails to produce similar
results in humans.
The U.S. National Cancer Institute has more about
lung cancer prevention.
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