-- Mary Elizabeth Dallas
THURSDAY, March 1 (HealthDay News) -- Scientists studying mice
say they better understand how marijuana impairs working memory,
the ability to momentarily retain and utilize information needed
for comprehension and learning.
The study, published in the March 2 print issue of
Cell, found that THC, the chief psychoactive ingredient in marijuana, impairs memory by affecting passive support cells known as astroglia, not active neurons as previously thought.
The memory changes are a major downside to the use of medical
marijuana, the researchers said.
With these experiments in mice, "we have found that the starting
point for this phenomenon -- the effect of marijuana on working
memory -- is the astroglial cells," researcher Giovanni Marsicano,
of INSERM in France, said in a journal news release. Evidence is
mounting that these cells play a more active role than once
believed in connecting neurons, not just nourishing them, he
The study authors said these cells, also known as astrocytes,
could have additional effects on other forms of memory. They said
their findings shed light on how the brain works and could
eventually help scientists find a way to deal with working memory
problems stemming from other causes.
Research involving animals should be considered preliminary
because the results often don't have implications for humans.
The U.S. National Institute on Drug Abuse has more about the
health effects of
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