-- Robert Preidt
TUESDAY, April 17 (HealthDay News) -- The ability to make
decisions in new situations declines with age, apparently because
of changes in the brain's white matter, a new imaging study
The researchers asked 25 adults, aged 21 to 85, to perform a
learning task involving money and also undergo MRI brain scans.
They found that age-related declines in decision-making are
associated with the weakening of two specific white-matter pathways
that connect an area called the medial prefrontal cortex (located
in the cerebral cortex) with two other areas deeper in the brain,
called the thalamus and the ventral striatum.
The medial prefrontal cortex is involved in decision-making, the
ventral striatum is involved in emotional and motivational aspects
of behavior, and the thalamus is a highly connected relay
"The evidence that this decline in decision-making is associated with white-matter integrity suggests that there may be effective ways to intervene," study first author Gregory Samanez-Larkin, a postdoctoral fellow in Vanderbilt University's psychology department and Institute of Imaging Science in Nashville, Tenn., said in a university news release. "Several studies have shown that white-matter connections can be strengthened by specific forms of cognitive training."
The study was published April 11 in the
Journal of Neuroscience.
Samanez-Larkin undertook this work while a graduate student at
Stanford University in Stanford, Calif.
The Society for Neuroscience explains how to
keep your brain healthy as you age.
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