MONDAY, May 7 (HealthDay News) -- If you're looking for a way to
keep dementia at bay, a new study suggests you can do so by
developing a firm purpose in life.
The findings don't prove that having a purpose will make a
difference, and it's possible that the researchers missed another
important factor that's at play. Still, the study found that people
who had more purpose -- as defined by the researchers -- seemed to
be less affected by the brain-clogging gunk that's considered to be
a cause of Alzheimer's disease.
"Somehow, having a purpose allows people to cope with the physical signs of Alzheimer's disease," said Patricia Boyle, an associate professor at the Rush Alzheimer's Disease Center at the Rush University Medical Center in Chicago.
Boyle and colleagues looked at tests given to 246 older people
who later died and underwent autopsies that explored the state of
The researchers defined a purpose in life as "the tendency to
find meaning from life experience, to be intentional and focused,"
Boyle said. "It's an indicator of well-being, that life is good and
you are contributing to your life, you're making decisions."
To determine purpose in life, the researchers analyzed answers
from a 10-item psychological test.
Among those who had a lot of brain gunk -- known as plaques and
tangles -- the ones who had greater purpose in life appeared to be
less affected by a decline in their mental (or "cognitive") powers.
"The rate of cognitive decline was about 30 percent slower for
someone with greater purpose in life, compared to someone with less
purpose," Boyle said.
The researchers found that they were able to link a higher sense
of purpose to better brain health even when they adjusted their
statistics so they wouldn't be thrown off by high or low numbers of
people with illness, signs of depression and other factors.
It's still not clear that purpose in life has anything to do
with mental powers in old age. But if there is a connection, it may
have something to do with the brain's capacity, said Dr. James
Burke, director of the Memory Disorders Clinic at Duke University
Similarly, people who have more education seem to be better able
to tolerate brain-clogging plaques and tangles without having as
many cognitive problems, Burke said. "My own analogy is that if a
city has more roads, it can tolerate more blocked roads while still
allowing you to get to your destination. This is commonly used as
the explanation, but difficult to prove."
The study is published in the May issue of the
Archives of General Psychiatry.
In other Alzheimer's disease news, a small new study indicates
that deep brain stimulation -- a treatment being tested to treat
mental problems -- seems to help the brain work more efficiently in
people who appear to have a mild form of the disease. (The disease
can't be conclusively diagnosed until after death.)
The researchers, Gwenn Smith of the Johns Hopkins University
School of Medicine and colleagues, examined four men and one woman
who underwent the treatment for a year.
In deep brain stimulation, the brain is zapped with an
electronic pulse that comes from a pacemaker-like device implanted
in the chest.
The study, which was published online May 7 in the
Archives of Neurology, was very small and "a very early look" at a new kind of treatment, noted Burke, who was not involved in the research. More research is needed, he added.
For more about
Alzheimer's disease, visit the U.S. National Library of Medicine.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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