-- Robert Preidt
FRIDAY, Oct. 19 (HealthDay News) -- A new French study supports
the use of radiation therapy after prostate cancer surgery to help
prevent recurrence in high-risk patients.
Surgery to remove the prostate (radical prostatectomy) is one of
the main treatments for prostate cancer. Experts, however, say the
risk of recurrence can be 10 percent to 50 percent in patients
whose cancer has already spread beyond the prostate, so
post-surgery radiation therapy is commonly prescribed for these
The new study included more than 1,000 high-risk prostate cancer
patients who had surgery and were followed for more than 10 years.
Some of them had immediate radiation therapy (given within four
months of surgery) while others were simply monitored for signs of
cancer recurrence (watchful waiting).
After 10 years, 61 percent of men who received immediate
radiation therapy remained cancer-free, compared with 38 percent of
those in the watchful waiting group, according to the study, which
was published online Oct. 18 in the journal
"These long-term results reassure us of the continued benefit and safety of radiation therapy after prostatectomy for a large proportion of men with locally advanced or high-risk prostate cancer," study leader Michel Bolla, a professor at the Centre Hospitalier Universitaire A Michallon, in France, said in a journal news release.
Bolla also noted that factors such as patient age or tumor
status could play into decisions around whether to use
radiotherapy. Younger patients, or those whose biopsy shows
evidence of cancer's spread, may gain from post-surgical radiation
treatments, whereas the therapy might cause more harm than benefit
for patients aged 70 or older.
Two specialists in the field said the findings come as little
"This study confirms what radiation oncologists have known for many years -- namely that certain adverse risk factors seen on final [laboratory results] after a prostatectomy warrant immediate postoperative radiation," said Dr. Jonathan Haas, chief of radiation oncology at Winthrop University Hospital in Mineola, N.Y.
Dr. Louis Potters, chairman of radiation medicine at North
Shore-LIJ Health System in New Hyde Park, N.Y., agreed.
"In certain men who have surgery for localized prostate cancer, post-operative radiation therapy is a powerful tool that can improve cancer outcomes," he said. Beyond offering certain patients "a second chance at a cure," post-op radiation treatment "also decreases the chances of needing future hormone therapy, which can have an array of unwanted side effects," Potters said.
But Haas stressed that teamwork is key to the proper care of any
patient with prostate cancer.
"This study underscores the need for close interdisciplinary cooperation between the urologist, radiation oncologist and pathologist to come up with a tailored treatment plan to maximize outcome for a given patient," he said.
The U.S. National Cancer Institute has more about
prostate cancer treatment.
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