-- Mary Elizabeth Dallas
THURSDAY, Oct. 25 (HealthDay News) -- Healthy middle-aged women
do not benefit from taking resveratrol supplements, new study
shows. Resveratrol is the ingredient in red wine thought to improve
insulin sensitivity, reduce the risk of heart disease and increase
Although resveratrol supplementation doesn't appear to help
these women, it's possible that another ingredient in red wine may
provide a health benefit, the researchers from the Washington
University School of Medicine in St. Louis pointed out.
"Resveratrol supplements have become popular because studies in cell systems and rodents show that resveratrol can improve metabolic function and prevent or reverse certain health problems like diabetes, heart disease and even cancer," senior investigator Dr. Samuel Klein, director of Washington University's Center for Human Nutrition, said in a university news release. "But our data demonstrate that resveratrol supplementation does not have metabolic benefits in relatively healthy, middle-aged women."
The study involved 29 postmenopausal women who were generally
healthy and did not have type 2 diabetes. The researchers had 15 of
the women take a 75 milligram over-the-counter resveratrol
supplement daily for 12 weeks. They noted that this was the
equivalent of drinking over two gallons of red wine. The insulin
sensitivity and metabolic response of these women was then compared
to 14 other women who took a inactive placebo pill over the course
of the study.
"It's the most sensitive approach we have for evaluating insulin action in people," said Klein. "And we were unable to detect any effect of resveratrol. In addition, we took small samples of muscle and fat tissue from these women to look for possible effects of resveratrol in the body's cells, and again, we could not find any changes in the signaling pathways involved in metabolism."
Previous studies suggested drinking red wine lowers the risk for
certain health problems, prompting many people to buy resveratrol
supplements to get the benefits of the ingredient without drinking
large amounts of alcohol. Annual sales of resveratrol supplements
in the United States have reached $30 million, the researchers
noted in the news release.
Based on the new findings, however, the study authors concluded
that the benefits of resveratrol may be limited to people who
already have a metabolic condition.
"Few studies have evaluated the effects of resveratrol in people," added Klein. "Those studies were conducted in people with diabetes, older adults with impaired glucose tolerance or obese people who had more metabolic problems than the women we studied. So it is possible that resveratrol could have beneficial effects in people who are more metabolically abnormal than the [healthy women] who participated in the study," he explained in the news release.
"The purpose of our study was not to identify the active ingredient in red wine that improves health but to determine whether supplementation with resveratrol has independent, metabolic effects in relatively healthy people," said Klein. "We were unable to detect a metabolic benefit of resveratrol supplementation in our study population, but this does not preclude the possibility that resveratrol could have a synergistic effect when combined with other compounds in red wine."
The study was published in the Oct. 25 online edition of the
The U.S. National Cancer Institute has more about
resveratrol and cancer prevention.
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