MONDAY, Feb. 11 (HealthDay News) -- Being born by cesarean
section has been tied to higher risks for various health problems
in children, and now a new study finds these babies also have fewer
"good" bacteria in their digestive tract.
Similarly, babies who were exclusively or even partially
formula-fed rather than breast-fed also had markedly different gut
flora than babies who were breast-fed, according to the study
appearing in the Feb. 11 issue of the
CMAJ (Canadian Medical Association Journal).
"Since other [researchers] have found associations between cesarean section delivery or formula-feeding and infant gut changes and conditions like allergy [and] asthma, we speculate that our observations may lead to poor health in later life," said study senior author Anita Kozyrskyj.
The findings support current clinical practice guidelines which
favor vaginal delivery whenever possible, added Kozyrskyj, who is
research chair and an associate professor of pediatrics at the
University of Alberta, in Edmonton.
About a third of all U.S. births occur by C-section, a number
considered by many to be far too high and potentially harmful to
both the child and the mother.
Vaginal delivery, among other advantages, fosters the growth of
trillions of good bacteria that reside peacefully in the human body
(collectively know as a person's microbiome), many of them in the
Meanwhile, C-sections interfere with the newborn's exposure to
bacteria in the vaginal tract, bacteria that essentially trains the
immune system to react appropriately to future events, according to
study background information.
Mothers who have C-sections also tend to start breast-feeding
later and require antibiotics, both of which could also affect the
In the new study, researchers analyzed DNA from fecal samples
taken from 24 healthy infants in four Canadian provinces at 4
months of age.
Compared with children who had been born vaginally, children who
had been delivered by C-section had less diverse flora, lower
Shigellabacteria and none of the bacteria known as
" Shigellaand Bacteroidesare organisms picked up from mom and considered first colonizers," Kozyrskyj explained. "They lay the foundation for further microbes that become part of our normal microbiome."
Meanwhile, infants who were fed formula as opposed to breast
milk also had less diverse flora and, in addition, had more of the
Clostridium difficile, which had been associated with the
development of allergies.
The study was a small one, but the researchers have collected
fecal samples on 200 children and will be analyzing those in the
future. They hope to eventually enroll 2,500 children in the
It's too soon to say definitively that the changes in the gut
microbiome of children born by C-section will develop health
problems. And it's possible that changes in the bacterial
composition of the intestine as people age will compensate for
diminished levels of bacteria in newborns, Kozyrskyj added.
A pediatric expert praised the new study.
"This is an important first step to make an association between intestinal bacteria and mode of delivery and type of feeding," said Dr. Michael Morowitz, a pediatric surgeon with Children's Hospital of Pittsburgh, at the University of Pittsburgh Medical Center.
Although follow-up studies will be needed, Morowitz added, "This
is the latest piece of pretty convincing evidence that determinants
very, very early in life can have an impact that lasts for months
National Institutes of Healthfor more on the Human Microbiome
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