-- Mary Elizabeth Dallas
MONDAY, April 9 (HealthDay News) -- Research in
vision-challenged pooches might pave the way to helping humans
battle similar problems, new research suggests.
A team at Michigan State University (MSU) believes insights into
an inherited condition that affects humans and dogs in similar ways
could help reverse vision loss in both species.
In 2010, research led by MSU veterinary ophthalmologist Dr.
Andras Komaromy showed that vision in dogs suffering from
achromatopsia, an inherited form of total color blindness, could be
restored by replacing the gene associated with the condition. This
treatment, however, was not effective for dogs older than 1 year of
Building on his earlier research, Komaromy theorized that
certain photoreceptor cells in the eyes called "cones" -- which
process light and color -- were simply too worn out in older
"Gene therapy only works if the nonfunctional cell that is primarily affected by the disease is not too degenerated," he said in a university news release. "That's how we came up with the idea for this new study. How about if we selectively destroy the light-sensitive part of the cones and let it grow back before performing gene therapy? Then you'd have a younger, less degenerated cell that may be more responsive to therapy."
The latest study involved dogs between 1 and 3 years old with
achromatopsia. Before replacing the mutant gene, the researchers
treated some of the dogs with a protein called CNTF that is used by
the central nervous system to keep cells healthy. The dogs were
given a dose high enough to partially destroy photoreceptors and
enable new growth.
"We were just amazed at what we found," Komaromy said. "All seven dogs that got the combination treatment responded, regardless of age."
Although achromatopsia is a rare condition in humans, the
study's authors pointed out that other disorders involving the
photoreceptors affect humans and dogs in similar ways. They
suggested that this combination treatment model also holds promise
for people with these conditions, although it should be noted that
success in animal research often does not translate to success in
"Based on our results, we are proposing a new concept of retinal therapy," Komaromy said. "One treatment option alone might not be enough to reverse vision loss, but a combination therapy can maximize success."
The study was funded by the U.S. National Eye Institute and the
Foundation Fighting Blindness, and was published online April 9 in
The U.S. National Institutes of Health provides more information
blindness and vision loss.
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