-- Robert Preidt
WEDNESDAY, June 19 (HealthDay News) -- A higher dose of
cholesterol-lowering statin drugs did not increase the risk of
kidney injury in heart attack survivors, according to preliminary
Statins have been shown to reduce the risk of a first heart
attack or repeat ones, but some recent studies have suggested that
higher doses of the drugs may be linked to a higher incidence of
To investigate the issue, researchers analyzed data from two
large clinical trials in which thousands of heart attack survivors
received either high- or low-dose statins. The investigators found
that higher doses did not increase the risk of hospitalization for
treatment of kidney injury.
The study also found that concentrations of a blood protein
called creatinine -- an indicator of kidney function -- were
comparable between the high- and low-dose statin groups during
The findings were presented Wednesday on the American Heart
Association's Emerging Science Series webinar.
"These findings provide important reassurance to clinicians that the use of some high-potency statins will not increase the risk of kidney injury," study lead author Dr. Amy Sarma, a resident physician in internal medicine at Brigham and Women's Hospital in Boston, said in an AHA news release.
The data and conclusions of unpublished research should be
considered preliminary until published in a peer-reviewed
The U.S. National Library of Medicine has more about
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