-- Robert Preidt
THURSDAY, Sept. 12 (HealthDay News) -- Researchers say they've
identified a gene mutation that's associated with a higher risk of
lung cancer in women who do not smoke, but a better chance of
survival in female and male lung cancer patients.
The mutation, which occurs in a gene that protects cells from
oxidative stress, is found four times more often in women than in
men, according to the study published Sept. 11 in the journal
The researchers analyzed the DNA of lung cancer patients in
Japan and found that nonsmoking women with two copies of the -617A
mutation in the NFR2 gene had a much higher incidence of lung
cancer than nonsmoking men.
The investigators also found that both female and male lung
cancer patients with this mutation had better survival rates than
This is the first study to provide clinical evidence that this
mutation is associated with lung cancer patient survival, said
researcher Dr. Toshihisa Ishikawa and colleagues at the RIKEN
Center for Life Science Technologies in Japan.
The study strongly suggests that the presence of this mutation
"is a good prognostic biomarker for the assessment of the overall
survival chances of patients with adenocarcinoma, as well as a
practical tool for personalized cancer therapy," Ishikawa said in a
RIKEN news release.
Although the study found an association between the gene
mutation and lung cancer survival, it did not prove a
Lung cancer is the leading cause of cancer-related deaths in
many industrialized countries, according to background information
in the news release. Smoking is the main cause of lung cancer, but
10 percent to 15 percent of cases occur in nonsmokers.
The U.S. National Cancer Institute has more about
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