-- Robert Preidt
THURSDAY, Feb. 13, 2014 (HealthDay News) -- Quick treatment with
a clot-busting drug limits brain damage in stroke patients -- even
those who are elderly or have had more severe strokes, new research
The drug -- called tissue plasminogen activator (tPA) -- is
widely used, but there is ongoing debate about when to give it and
whether it's safe to use in older patients or in those with minor
or severe stroke.
A team of British experts reviewed data from more than 6,700
stroke patients who took part in nine clinical trials. They found
that tPA reduced patients' risk of long-term disability and that
earlier treatment improved outcomes.
The review showed that 33 percent of patients who were given tPA
within three hours of the start of stroke symptoms did not have
significant disability three to six months later, compared with 23
percent of those who did not receive the drug.
The rates were 35 percent for those who received the drug
between three and four and a half hours after the onset of
symptoms, and 33 percent for those who received it more than four
and a half hours later. The rates were 30 percent and 31 percent,
respectively, for patients who weren't given tPA.
The study was presented Wednesday at a meeting of the American
Stroke Association in San Diego. Research presented at medical
meetings should be considered preliminary until published in a
"Our results may have implications for treatment guidelines on both sides of the Atlantic," study author Jonathan Emberson, senior statistician at the University of Oxford in the United Kingdom, said in an association news release.
"In the United States, use of tPA is currently limited to treatment within three hours, while in some European countries use is limited to patients aged 80 or younger," Emberson said. "The appropriateness of both of these restrictions may be revisited in light of our results."
Study co-author Peter Sandercock, a professor of neurology at
the University of Edinburgh in Scotland, said tPA is under-used in
stroke patients over age 80. "I am delighted these data support the
use of tPA in this somewhat neglected patient group," he said.
About 795,000 Americans suffer a stroke each year, according to
the American Stroke Association.
The U.S. National Institute of Neurological Disorders and Stroke
has more about
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