Methyldopa is a medication that is sometimes used to control hypertension; however, it is not a first-line treatment due to the various health risks associated with its use.
There is some evidence that methyldopa might impair the body's ability to manufacture the substance coenzyme Q
supplements might make sense as a general precaution, but no specific benefit has been established.
Iron supplements can interfere with the absorption of methyldopa, so make sure you do not take iron during the 2 hours before or after your methyldopa dose.2,3
Kishi H, et al. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q
-enzymes by clinically used anti-hypertensive drugs.
Res Commun Chem Pathol Pharmacol
12(3): 533–540, 1975.
Campbell NR and Hasinoff BB. Iron supplements: A common cause of drug interactions.
Br J Clin Pharmacol
31: 251–255, 1991.
Campbell N, Paddock V, and Sundaram R. Alteration of methyldopa absorption, metabolism, and blood pressure control caused by ferrous sulfate and gluconate.
Clin Pharmacol Ther
43: 381–386, 1988.
Last reviewed September 2014 by EBSCO CAM Review Board
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